7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde

Base Information

Chemical Name:7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde
CAS No.:37854-59-4
Molecular Formula:C₁₃H₁₀N₄O₃
Molecular Weight:270.247
Hs Code.:2933990090
ChEMBL ID:CHEMBL1397270
DSSTox Substance ID:DTXSID70590847
Nikkaji Number:J2.023.505E
Pharos Ligand ID:9QG71SNDFTL7
Wikidata:Q27163808
Mol file:37854-59-4.mol

Synonyms:7,10-dimethyl-2,4-dioxobenzo(g)pteridine-8-carbaldehyde;Ro-08-2750

Suppliers and Price of 7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Ro 08-2750
1mg
$ 333.00

TRC
Ro08-2750
1mg
$ 160.00

Tocris
Ro08-2750 ≥95%(HPLC)
1
$ 101.00

Tocris
Ro08-2750 ≥95%(HPLC)
50
$ 887.00

Tocris
Ro08-2750 ≥95%(HPLC)
10
$ 216.00

Cayman Chemical
Ro 08-2750
5mg
$ 102.00

Cayman Chemical
Ro 08-2750
10mg
$ 189.00

Cayman Chemical
Ro 08-2750
1mg
$ 32.00

ApexBio Technology
Ro08-2750
1mg
$ 150.00

American Custom Chemicals Corporation
RO 08-2750 95.00%
5MG
$ 505.51

Total 11 raw suppliers

Chemical Property of 7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde

Chemical Property:

PSA：97.71000
Density:1.57g/cm³
LogP:0.29090
Storage Temp.:Store at -20°C
Solubility.:≤2.7mg/ml in DMSO
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:270.07529019
Heavy Atom Count:20
Complexity:554

Purity/Quality:

97% ^*data from raw suppliers

Ro 08-2750 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(C=C1C=O)N(C3=NC(=O)NC(=O)C3=N2)C
Uses Ro 08-2750 is a TrkA inhibitor and NGF-induced apoptosis inhibitor.

Technology Process of 7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde

There total 6 articles about 7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₀Br₂N₄O₂

: 37854-59-4
Ro 08-2750

Guidance literature:: With water; In tetrahydrofuran; at 60 ℃; Cooling with ice;
DOI:10.1021/jacs.6b02469

Reference yield:

: 6972-71-0
4,5-dimethyl-2-nitrobenzenamine

: 37854-59-4
Ro 08-2750

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / water / 3 h / 65 °C

2: sodium tetrahydroborate; palladium 10% on activated carbon / methanol / 0.67 h / 20 °C / Inert atmosphere

3: boric acid / acetic acid / 12 h / Inert atmosphere

4: sulfuric acid; bromine / 120 h / 50 °C

5: water / tetrahydrofuran / 60 °C / Cooling with ice

With sodium tetrahydroborate; sulfuric acid; palladium 10% on activated carbon; water; bromine; boric acid; In tetrahydrofuran; methanol; water; acetic acid;
DOI:10.1021/jacs.6b02469

Reference yield:

: 17978-54-0
N¹,4,5-trimethyl-2-nitroaniline

: 37854-59-4
Ro 08-2750

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; palladium 10% on activated carbon / methanol / 0.67 h / 20 °C / Inert atmosphere

2: boric acid / acetic acid / 12 h / Inert atmosphere

3: sulfuric acid; bromine / 120 h / 50 °C

4: water / tetrahydrofuran / 60 °C / Cooling with ice

With sodium tetrahydroborate; sulfuric acid; palladium 10% on activated carbon; water; bromine; boric acid; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1021/jacs.6b02469