7-(3-hydroxy-5-oxo-1-cyclopenten-1-yl)-(5Z)--Heptenoic acid-1-Methylethyl ester

Base Information

Chemical Name:7-(3-hydroxy-5-oxo-1-cyclopenten-1-yl)-(5Z)--Heptenoic acid-1-Methylethyl ester
CAS No.:81834-79-9
Molecular Formula:C₁₅H₂₂O₄
Molecular Weight:266.337
Hs Code.:
Mol file:81834-79-9.mol

Synonyms:7-(3-hydroxy-5-oxo-1-cyclopenten-1-yl)-(5Z)--Heptenoic acid-1-Methylethyl ester;(5Z)-7-(3-Hydroxy-5-oxo-1-cyclopenten-1-yl)-5-heptenoic acid 1-methylethyl ester

Suppliers and Price of 7-(3-hydroxy-5-oxo-1-cyclopenten-1-yl)-(5Z)--Heptenoic acid-1-Methylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of 7-(3-hydroxy-5-oxo-1-cyclopenten-1-yl)-(5Z)--Heptenoic acid-1-Methylethyl ester

Chemical Property:

PSA：63.60000
LogP:2.31470

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 7-(3-hydroxy-5-oxo-1-cyclopenten-1-yl)-(5Z)--Heptenoic acid-1-Methylethyl ester

There total 24 articles about 7-(3-hydroxy-5-oxo-1-cyclopenten-1-yl)-(5Z)--Heptenoic acid-1-Methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190883-10-3
(Z)-8-(furan-2-yl)-8-hydroxyoct-5-enoate

: 81834-79-9
isopropyl (Z)-7-(3-hydroxy-5-oxo-cyclopent-1-en-1-yl)-hept-5-enoate

Guidance literature:: (Z)-8-(furan-2-yl)-8-hydroxyoct-5-enoate; With hydroquinone; zinc(II) chloride; In 1,4-dioxane; for 15h; Inert atmosphere; Reflux;

With chloral; triethylamine; In toluene; for 15h;

Reference yield:

: 1190883-10-3
(Z)-8-(furan-2-yl)-8-hydroxyoct-5-enoate

: 1190883-24-9
isopropyl (Z)-7-(2-hydroxy-5-oxo-cyclopent-3-enyl)-hept-5-enoate

: 81834-79-9
isopropyl (Z)-7-(3-hydroxy-5-oxo-cyclopent-1-en-1-yl)-hept-5-enoate

Guidance literature:: With hydroquinone; zinc(II) chloride; In 1,4-dioxane; Inert atmosphere; Reflux;

Reference yield:

: 98-01-1
furfural

: 81834-79-9
isopropyl (Z)-7-(3-hydroxy-5-oxo-cyclopent-1-en-1-yl)-hept-5-enoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: zinc / tetrahydrofuran / 60 - 65 °C

2.1: tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Large scale

3.1: potassium osmate; 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine; 4-methylmorpholine N-oxide / acetone; water / 8.5 h / 10 - 25 °C / Large scale

4.1: sodium periodate / acetone; water / 33 h / 10 - 30 °C / Inert atmosphere; Large scale

5.1: sodium hexamethyldisilazane; tris(pyrrolidino)phosphine oxide / tetrahydrofuran / 1.4 h / 0 - 10 °C / Inert atmosphere; Large scale

5.2: 1 h / -38 - -32 °C / Inert atmosphere; Large scale

6.1: potassium carbonate / acetone / 4 h / Reflux; Large scale

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran; water / 35 - 40 °C / Large scale

8.1: zinc(II) chloride; hydroquinone / water; 1,4-dioxane / 6 h / Inert atmosphere; Reflux; Large scale

8.2: 15 h / 20 °C / Inert atmosphere; Large scale

With potassium osmate; sodium periodate; tris(pyrrolidino)phosphine oxide; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; potassium carbonate; 4-methylmorpholine N-oxide; 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine; hydroquinone; zinc(II) chloride; zinc; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; 5.2: |Wittig Olefination;
DOI:10.1021/op300188x