Technology Process of 1-(3,5-Di-O-benzoyl-2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
There total 4 articles about 1-(3,5-Di-O-benzoyl-2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C19H16BrFO5; O,O'-bis-(trimethylsilyl)uracil;
In
chloroform;
for 18h;
Reflux;
Inert atmosphere;
With
water;
In
chloroform;
at 20 ℃;
for 0.5h;
-
-
3080-30-6,6974-32-9,14215-97-5,16162-35-9,20822-87-1,21138-42-1,22249-15-6,22249-17-8,26287-72-9,53403-35-3,53403-36-4,57236-69-8,70832-64-3,99395-04-7,100101-51-7,109668-83-9,120019-54-7
1-O-acetyl-2,3,5-tri-O-benzoyl-β-L-ribofuranose
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Acetyl bromide; methanol / dichloromethane / 2 h / 0 °C
1.2: 2 h / 20 °C
2.1: diethylaminosulfur trifluoride / dichloromethane / 24 h / Reflux
3.1: hydrogen bromide; acetic acid / dichloromethane / 17 h / Inert atmosphere
4.1: chloroform / 18 h / Reflux; Inert atmosphere
4.2: 0.5 h / 20 °C
With
methanol; Acetyl bromide; hydrogen bromide; acetic acid; diethylaminosulfur trifluoride;
In
dichloromethane; chloroform;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diethylaminosulfur trifluoride / dichloromethane / 24 h / Reflux
2.1: hydrogen bromide; acetic acid / dichloromethane / 17 h / Inert atmosphere
3.1: chloroform / 18 h / Reflux; Inert atmosphere
3.2: 0.5 h / 20 °C
With
hydrogen bromide; acetic acid; diethylaminosulfur trifluoride;
In
dichloromethane; chloroform;
