Technology Process of 7-Oxa-2-azaspiro[4.5]decane
There total 6 articles about 7-Oxa-2-azaspiro[4.5]decane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 - 30 ℃;
for 12h;
under 7500.75 - 15001.5 Torr;
Autoclave;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N,N,N,N,-tetramethylethylenediamine; sodium hexamethyldisilazane / tetrahydrofuran / 4 h / -65 - -40 °C
2: sodium hydroxide; water / methanol / 3 h / 5 - 20 °C
3: (R)-1-(1-Naphthyl)ethylamine / acetonitrile / 2 h / 10 - 25 °C
4: sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 2 h / 5 - 20 °C
5: potassium carbonate / methanol / 12 h / 45 - 55 °C
6: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 20 - 30 °C / 7500.75 - 15001.5 Torr / Autoclave
With
sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex; N,N,N,N,-tetramethylethylenediamine; palladium 10% on activated carbon; (R)-1-(1-Naphthyl)ethylamine; water; hydrogen; sodium hexamethyldisilazane; potassium carbonate; sodium hydroxide;
In
tetrahydrofuran; methanol; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydroxide; water / methanol / 3 h / 5 - 20 °C
2: (R)-1-(1-Naphthyl)ethylamine / acetonitrile / 2 h / 10 - 25 °C
3: sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 2 h / 5 - 20 °C
4: potassium carbonate / methanol / 12 h / 45 - 55 °C
5: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 20 - 30 °C / 7500.75 - 15001.5 Torr / Autoclave
With
sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex; palladium 10% on activated carbon; (R)-1-(1-Naphthyl)ethylamine; water; hydrogen; potassium carbonate; sodium hydroxide;
In
tetrahydrofuran; methanol; acetonitrile;
