Fenofibrate-d6

Base Information

• Chemical Name: Fenofibrate-d6
• CAS No.: 1092484-56-4
• Molecular Formula: C20H21ClO4
• Molecular Weight: 360.83134
• Mol file: 1092484-56-4.mol

Synonyms:LF 178-d6;2-[4-(4-Chlorobenzoyl)phenoxy]-2-methyl-propanoic Acid-d6 1-Methylethyl Ester;Fenofibrate-d6;Lipanthyl-d6;Lipantil-d6;Lipidil Supra-d6;Lipirex-d6;Lipoclar-d6

Chemical Property of Fenofibrate-d6

Chemical Property:

• Melting Point: 70-720C
• PSA: 52.60000
• LogP: 4.68000
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Sightly)

Purity/Quality:

98% by HPLC; 99% atom D ^*data from raw suppliers

Fenofibrate-d6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Fenofibrate-d6 is intended for use as an internal standard for the quantification of fenofibrate by GC- or LC-MS. Fenofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 values of 18 and 30 μM for mouse and human receptors, respectively, in a transactivation assay. It is selective for PPARα over PPARγ (EC50s = 300 and 200 μM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARδ at a concentration of 100 μM. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner. It decreases glomerular and tubular atrophy and necrosis induced by cisplatin in rat kidney when administered at a dose of 100 mg/kg. Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung of Tsumura Suzuki obese diabetic (TSOD) mice.
• Uses: Antilipemic. It is a lipid regulating drug. Increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expresion.