(5-P-TOLYLISOXAZOL-3-YL)METHANOL

Base Information

• Chemical Name: (5-P-TOLYLISOXAZOL-3-YL)METHANOL
• CAS No.: 640291-93-6
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.214
• Hs Code.: 2934999090
• Mol file: 640291-93-6.mol

Synonyms:SALOR-INT L482706-1EA;(5-P-TOLYLISOXAZOL-3-YL)METHANOL;AKOS PAO-1440;5-(4-METHYLPHENYL)-3-ISOXAZOLEMETHANOL;[5-(4-methylphenyl)isoxazol-3-yl]methanol(SALTDATA: FREE);[5-(4-methylphenyl)-1,2-oxazol-3-yl]methanol

Chemical Property of (5-P-TOLYLISOXAZOL-3-YL)METHANOL

Chemical Property:

• PSA: 46.26000
• LogP: 2.14230

Purity/Quality:

98%Min ^*data from raw suppliers

[5-(4-methylphenyl)isoxazol-3-yl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-P-TOLYLISOXAZOL-3-YL)METHANOL

There total 8 articles about (5-P-TOLYLISOXAZOL-3-YL)METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 5-(p-tolyl)isoxazole-3-carboxylate (517870-14-3) → [5-(4-methylphenyl)-1,2-oxazol-3-yl]methanol (640291-93-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 50 ℃; for 5h;

DOI:10.1016/j.ejmech.2019.111635

Reference yield: 75.0%

5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde (640292-02-0) → [5-(4-methylphenyl)-1,2-oxazol-3-yl]methanol (640291-93-6)

Guidance literature:

With sodium tetrahydroborate; isopropyl alcohol; for 4h;

DOI:10.1134/S1070428013100205

Reference yield:

ethyl-4-(4-methylphenyl)-2,4-dioxobutyrate (5814-37-9) → [5-(4-methylphenyl)-1,2-oxazol-3-yl]methanol (640291-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂OH*HCl / ethanol / 1 h / Heating

2: LiAlH₄ / diethyl ether / 0.5 h / 40 °C

With lithium aluminium tetrahydride; hydroxylamine hydrochloride; In diethyl ether; ethanol;

DOI:10.1055/s-2003-41072

upstream raw materials:

ethyl-4-(4-methylphenyl)-2,4-dioxobutyrate

para-methylacetophenone

5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde

3-hydroxyiminomethyl-5-p-tolylisoxazole

Downstream raw materials:

5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde

2-amino-3-cyano-7-dimethylamino-4-(5-(4-methylphenyl)-isoxazol-3-yl)-4H-chromene

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