N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE

Base Information

• Chemical Name: N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE
• CAS No.: 5329-15-7
• Molecular Formula: C9H12 N2 O2
• Molecular Weight: 180.206
• Hs Code.: 2924299090
• Mol file: 5329-15-7.mol

Synonyms:o-Acetanisidide,4'-amino- (6CI,7CI,8CI); 2-Methoxy-4-aminoacetanilide;4-Acetamido-3-methoxyaniline; N-(4-Amino-2-methoxyphenyl)acetamide; NSC 1873;NSC 7551

Chemical Property of N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE

Chemical Property:

• Vapor Pressure: 0.00373mmHg at 25°C
• Melting Point: 119-120 °C
• Boiling Point: 280.7°Cat760mmHg
• PKA: 14.12±0.70(Predicted)
• Flash Point: 123.6°C
• PSA: 64.35000
• Density: 1.211g/cm³
• LogP: 1.89000

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-amino-2-methoxyphenyl)acetamidehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE

There total 4 articles about N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

5-nitro-2-acetylaminoanisole (93-27-6) → N-(4-amino-2-methoxyphenyl)acetamide (5329-15-7)

Guidance literature:

With iron; acetic acid; In water; for 2h; Reflux;

DOI:10.1002/cmdc.201700243

Reference yield:

2-methoxy-4-nitrophenylamine (97-52-9) → N-(4-amino-2-methoxyphenyl)acetamide (5329-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / acetic acid / 1 h / 80 °C

2: H₂ / Raney nickel / methanol / 22.5 h / 2585.7 Torr

With hydrogen; nickel; In methanol; acetic acid;

DOI:10.1002/jhet.5570260542

Reference yield:

2-methoxy-4-nitrophenylamine (97-52-9) → N-(4-amino-2-methoxyphenyl)acetamide (5329-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2 h / 120 °C

2: 5% Pd(II)/C(eggshell) / ethyl acetate / 8 h / 20 °C

With 5% Pd(II)/C(eggshell); In pyridine; ethyl acetate;

DOI:10.1021/ic200032e

upstream raw materials:

5-nitro-2-acetylaminoanisole

2-methoxy-4-nitrophenylamine

N-(2-hydroxy-4-nitrophenyl)acetamide

Downstream raw materials:

C₁₁H₁₆N₂O₂

N,N'-bis-(4-amino-3-methoxy-phenyl)-urea

4-bromo-1-iodo-2-methoxybenzene

9-(4-Methanesulfonylamino-2-methoxy-phenylamino)-5-methyl-acridine-4-carboxylic acid methylamide; hydrochloride