3-AMino-1-Methylpiperidin-2-one hydrochloride

Base Information

• Chemical Name: 3-AMino-1-Methylpiperidin-2-one hydrochloride
• CAS No.: 1422130-18-4
• Molecular Formula: C6H13ClN2O
• Molecular Weight: 164.63322
• Mol file: 1422130-18-4.mol

Synonyms:3-AMino-1-Methylpiperidin-2-one hydrochloride

Chemical Property of 3-AMino-1-Methylpiperidin-2-one hydrochloride

Chemical Property:

• PSA: 46.33000
• LogP: 1.00610

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-Amino-1-methylpiperidin-2-onehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMino-1-Methylpiperidin-2-one hydrochloride

There total 2 articles about 3-AMino-1-Methylpiperidin-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (1-methyl-2-oxopiperidin-3-yl)carbamate → 3-amino-1-methylpiperidin-2-one hydrochloride (1422130-18-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃;

Reference yield:

(+/-)-3-<(tert-butoxycarbonyl)amino>-2-piperidone (99780-98-0) → 3-amino-1-methylpiperidin-2-one hydrochloride (1422130-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; sodium hydride; In ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

3-amino-1-methylpiperidin-2-one hydrochloride (1422130-18-4) → C24H26F6N4O2S (1422128-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol / 20 °C

2: piperdinium acetate / isopropyl alcohol / 60 °C

With piperdinium acetate; triethylamine; In ethanol; isopropyl alcohol;

upstream raw materials:

(+/-)-3-<(tert-butoxycarbonyl)amino>-2-piperidone

Downstream raw materials:

C₂₄H₂₆F₆N₄O₂S

Refernces