Gvapspat amide

Base Information

• Chemical Name: Gvapspat amide
• CAS No.: 93208-51-6
• Molecular Formula: C46H60 N12 O12
• Molecular Weight: 973.04
• Nikkaji Number: J678.103I
• Mol file: 93208-51-6.mol

Synonyms:Glu-Val-Asn-Phe-Ser-Pro-Asn-Trp-NH2;glutamyl-valyl-asparaginyl-phenylalanyl-seryl-prolyl-asparaginyl-tryptophanamide;GVAPSPAT amide;hypertrehalosemic hormone I;hypertrehalosemic peptide I;neurohormone D;neurohormone D, Periplaneta americana;Pea-CAH-I

Chemical Property of Gvapspat amide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1602.6°Cat760mmHg
• Flash Point: 923°C
• PSA: 389.30000
• Density: 1.387g/cm³
• LogP: 0.72890
• XLogP3: -2.7
• Hydrogen Bond Donor Count: 12
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 24
• Exact Mass: 972.44536540
• Heavy Atom Count: 70
• Complexity: 1960

Purity/Quality:

MYOACTIVE PEPTIDE I-COCKROACH 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CO)C(=O)N2CCCC2C(=O)NC(CC(=O)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)NC(=O)C5CCC(=O)N5
• Isomeric SMILES: CC(C)[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N)NC(=O)[C@@H]5CCC(=O)N5

Technology Process of Gvapspat amide

There total 19 articles about Gvapspat amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

N-benzyloxycarbonyl-L-pyro-glutamyl-L-valyl-L-asparginyl-L-phenylalanyl-L-seryl-L-prolyl-L-asparginyl-L-tryptophane amide (130619-29-3) → periplanetin CC-1 (93208-51-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; acetic acid; for 2h;

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → periplanetin CC-1 (93208-51-6)

Guidance literature:

Multi-step reaction with 10 steps

1: 42 percent / triethylamine (TEA), N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / tetrahydrofuran; ethanol / 72 h

2: 71 percent / 4 N HCl / dioxane

3: triethylamine (TEA) / CHCl₃

4: 72 percent / H₂ / 10percent Pd/C / methanol; acetic acid / 4 h

5: 75 percent / diphenylphosphorylazide (DPPA), triethylamine (TEA) / dimethylformamide / 72 h / 4 °C

6: 80 percent / 2 N HCl / dioxane

7: 71 percent / amyl nitrite, 2 N HCl / dimethylformamide; dioxane

8: 57.5 percent / 4 N HCl / dioxane

9: triethylamine (TEA) / CHCl₃

10: 54 percent / H₂ / 10percent Pd/C / acetic acid; methanol / 2 h

With hydrogenchloride; n-Amyl nitrite; diphenylphosphoranyl azide; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; acetic acid; N,N-dimethyl-formamide;

Reference yield:

t-Boc-L-valine (13734-41-3) → periplanetin CC-1 (93208-51-6)

Guidance literature:

Multi-step reaction with 7 steps

1: dicyclocarbodiimide / CH₂Cl₂ / 2 h / 4 °C

2: triethylamine (TEA) / CH₂Cl₂ / 20 h / Ambient temperature

3: 45 percent / hydrazine hydrate / methanol / 72 h / Ambient temperature

4: 71 percent / amyl nitrite, 2 N HCl / dimethylformamide; dioxane

5: 57.5 percent / 4 N HCl / dioxane

6: triethylamine (TEA) / CHCl₃

7: 54 percent / H₂ / 10percent Pd/C / acetic acid; methanol / 2 h

With hydrogenchloride; n-Amyl nitrite; hydrogen; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; chloroform; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

N-benzyloxycarbonyl-L-pyro-glutamyl-L-valyl-L-asparginyl-L-phenylalanyl-L-seryl-L-prolyl-L-asparginyl-L-tryptophane amide

1-(tert-butoxycarbonyl)-L-proline

t-Boc-L-valine

L-asparginyl-L-phenylalanyl methyl ester

Refernces