Praziquantel-d11

Base Information

• Chemical Name: Praziquantel-d11
• CAS No.: 1246343-36-1
• Molecular Formula: C19H24N2O2
• Molecular Weight: 312.40606
• Mol file: 1246343-36-1.mol

Synonyms:Praziquantel-d11;2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-(pyrazino-d11)[2,1-a]isoquinolin-4-one;Azinox-d11;Biltricide-d11;Cesol-d11;Cysticide-d11;Distocide-d11;Droncit-d11

Chemical Property of Praziquantel-d11

Chemical Property:

• PSA: 40.62000
• LogP: 2.41070
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Praziquantel-d11 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Praziquantel-d11 is intended for use as an internal standard for the quantification of praziquantel by GC- or LC-MS. Praziquantel is an anthelmintic agent. It is lethal to S. mansoni schistosomula and adults (LC50s = 0.68 and 0.03 mg/ml, respectively). Praziquantel (172 and 592 mg/kg) reduces worm burden in a mouse model of S. mansoni infection. Formulations containing praziquantel have been used in the treatment of schistosomiasis.
• Uses: Praziquantel-d11 can be intended for use as an internal standard for the quantification of Praziquantel by GC- or LC-mass spectrometry. Labelled Praziquantel (P702095). Anthelmintic, effective against flatworms. As Labelled Praziquantel (P702095), Praziquantel-d11 can beused as Anthelmintic, effective against flatworms.

Technology Process of Praziquantel-d11

There total 2 articles about Praziquantel-d11 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C7(2)H11ClO + 2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (61196-37-0,55375-90-1) → 2-(cyclohexane-d11-carbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (1246343-36-1,1399880-38-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

[1,2,2,3,3,4,4,5,5,6,6-2H11]cyclohexanecarboxylic acid (93131-16-9) → 2-(cyclohexane-d11-carbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (1246343-36-1,1399880-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 1 h / 60 °C

2: triethylamine / dichloromethane / 3 h / 20 °C

With thionyl chloride; triethylamine; In dichloromethane; toluene;

upstream raw materials:

[1,2,2,3,3,4,4,5,5,6,6-2H₁₁]cyclohexanecarboxylic acid

2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one