17β-HydroxyMethyl-17α-Methyl-18-norandrosta-1,4,13-trien-3-one

Base Information

Chemical Name:17β-HydroxyMethyl-17α-Methyl-18-norandrosta-1,4,13-trien-3-one
CAS No.:912291-78-2
Molecular Formula:C20H26O2
Molecular Weight:298.425
Hs Code.:
Mol file:912291-78-2.mol

Synonyms:17β-HydroxyMethyl-17α-Methyl-18-norandrosta-1,4,13-trien-3-one

Suppliers and Price of 17β-HydroxyMethyl-17α-Methyl-18-norandrosta-1,4,13-trien-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of 17β-HydroxyMethyl-17α-Methyl-18-norandrosta-1,4,13-trien-3-one

Chemical Property:

PSA：37.30000
LogP:3.96700

Purity/Quality:: 99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A new urinary metabolite of the human doping Metandienone (Methandrostenolone, M226000). This metabolite was reported to be detected in urine samples up to 19 days after administration of Metandienone. 17β-Hydroxymethyl-17α-methyl-18-norandrosta-1,4,13-trien-3-one is a new urinary labelled metabolite of the human doping Metandienone (Methandrostenolone, M226000). This metabolite was reported to be detected in urine samples up to 19 days after administration of Metandienone.

Technology Process of 17β-HydroxyMethyl-17α-Methyl-18-norandrosta-1,4,13-trien-3-one

There total 19 articles about 17β-HydroxyMethyl-17α-Methyl-18-norandrosta-1,4,13-trien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 17β-acetoxymethyl-17α-methyl-18-norandrosta-1,4,13-trien-3-on

: 912291-78-2,1203575-20-5
18-nor-17β-hydroxymethyl-17α-methylandrost-1,4,13-triene-3-one

Guidance literature:: With potassium carbonate; In methanol; for 5h;
DOI:10.1002/chem.201602957

Reference yield: 22.0%

: 55706-91-7
spiro(13α-methylandrost-1,4-dien-17,2'-oxirane)-3-one

: 912291-78-2,1203575-20-5
18-nor-17β-hydroxymethyl-17α-methylandrost-1,4,13-triene-3-one

Guidance literature:: With phosphoric acid; In water; toluene; Reflux;
DOI:10.1016/j.steroids.2016.08.013

Reference yield:

: 3β-[(tert-butyldimethylsilyl)oxy]-13α,14α-epoxy-17α-formyl-17β-methyl-18-norandrost-5-ene

: 912291-78-2,1203575-20-5
18-nor-17β-hydroxymethyl-17α-methylandrost-1,4,13-triene-3-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: dichloromethane / 20 °C / Molecular sieve

1.2: 0.5 h / 20 °C / Molecular sieve

2.1: acetic acid; [bis(acetoxy)iodo]benzene; palladium diacetate / 0.75 h / 100 °C

3.1: methyl trifluoromethanesulfonate / dichloromethane / 2 h

4.1: sodium tetrahydroborate / ethanol / 0.67 h / 0 °C

4.2: 5 h / 20 °C

5.1: zinc trifluoromethanesulfonate / acetonitrile / 4 h

6.1: nickel / water; ethanol; ethyl acetate / 1 h / 80 °C / Inert atmosphere

7.1: tungsten(VI) chloride; n-butyllithium; lithium iodide / hexane; tetrahydrofuran / 0.33 h / -78 - 40 °C / Inert atmosphere

8.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0 °C

8.2: 4 h / 60 °C

9.1: sodium hydrogencarbonate; C₁₃H₁₀O₃Se₂ / toluene / 1.25 h / 100 °C

10.1: potassium carbonate / methanol / 5 h

With sodium tetrahydroborate; n-butyllithium; [bis(acetoxy)iodo]benzene; C₁₃H₁₀O₃Se₂; palladium diacetate; zinc trifluoromethanesulfonate; nickel; tungsten(VI) chloride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; acetic acid; methyl trifluoromethanesulfonate; lithium iodide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1002/chem.201602957