(S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylicacidmethylester

Base Information

• Chemical Name: (S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylicacidmethylester
• CAS No.: 932736-90-8
• Molecular Formula: C₂₄H₂₉NO₃
• Molecular Weight: 379.499
• Mol file: 932736-90-8.mol

Synonyms:(±)-PPCC oxalate;(S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylicacidmethylester;(1R,2S)-rel-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylic acid methyl ester;(±)-PPCC

Chemical Property of (S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylicacidmethylester

Chemical Property:

• PSA: 248.74000
• LogP: 5.00560
• Storage Temp.: Store at +4°C

Purity/Quality:

99% ^*data from raw suppliers

(+/-)-PPCC OXALATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (±)-PPCC Oxalate is a novel σ receptor ligand.

Technology Process of (S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylicacidmethylester

There total 4 articles about (S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylicacidmethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-hydroxy-4-phenylpiperidin (40807-61-2) + (+)-methyl (1R,2S)-2-(bromomethyl)-1-(4-methylphenyl)cyclopropanecarboxylate (1236217-59-6) → (+)-methyl (1R,2S)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate (1236217-63-2,932736-90-8)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 60 ℃; for 8h; Inert atmosphere;

DOI:10.1021/jm100116p

Reference yield: 80.0%

4-hydroxy-4-phenylpiperidin (40807-61-2) + (-)-methyl (1S,2R)-2-(bromomethyl)-1-(4-methylphenyl)cyclopropanecarboxylate (1236217-61-0) → (-)-methyl (1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate (1236217-65-4,932736-90-8)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 60 ℃; for 8h; Inert atmosphere;

DOI:10.1021/jm100116p

Reference yield:

methyl (1RS,2SR)-2-(chloromethyl)-1-(4-methylphenyl)cyclopropanecarboxylate + 4-hydroxy-4-phenylpiperidin (40807-61-2) → cis-(+/-)-methyl (1R,2S/1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate (932736-90-8)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1021/jm0611197

upstream raw materials:

4-hydroxy-4-phenylpiperidin

(+)-methyl (1R,2S)-2-(bromomethyl)-1-(4-methylphenyl)cyclopropanecarboxylate

(-)-methyl (1S,2R)-2-(bromomethyl)-1-(4-methylphenyl)cyclopropanecarboxylate

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