5-chloro-3-fluoropicolinaldehyde

Base Information

• Chemical Name: 5-chloro-3-fluoropicolinaldehyde
• CAS No.: 214055-11-5
• Molecular Formula: C₆H₃ClFNO
• Molecular Weight: 159.547
• Hs Code.: 2933399990
• Mol file: 214055-11-5.mol

Synonyms:5-chloro-3-fluoropicolinaldehyde;5-chloro-3-fluoropyridine-2-carbaldehyde

Chemical Property of 5-chloro-3-fluoropicolinaldehyde

Chemical Property:

• Boiling Point: 188.7±35.0 °C(Predicted)
• PKA: -1.03±0.10(Predicted)
• PSA: 29.96000
• Density: 1.444±0.06 g/cm3(Predicted)
• LogP: 1.68660
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-3-fluoropyridine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-3-fluoropicolinaldehyde

There total 5 articles about 5-chloro-3-fluoropicolinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-chloro-3-fluoro-N-methoxy-N-methylpicolinamide (1600511-96-3) → 5-chloro-3-fluoropyridine-2-carbaldehyde (214055-11-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 0 ℃; for 3h;

Reference yield:

(5-chloro-3-fluoropyridin-2-yl)methanol (214055-12-6) → 5-chloro-3-fluoropyridine-2-carbaldehyde (214055-11-5)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 43.5h;

Reference yield:

3-fluoro-5-chloro-2-pyridinecarboxylic acid ethyl ester (207994-06-7) → 5-chloro-3-fluoropyridine-2-carbaldehyde (214055-11-5)

Guidance literature:

With sodium borohydrid; In water; tert-butyl alcohol;

upstream raw materials:

3-fluoro-5-chloro-2-pyridinecarboxylic acid ethyl ester

5-chloro-3-fluoro-2-pyridinecarboxylic acid

5-chloro-3-fluoro-N-methoxy-N-methylpicolinamide

(5-chloro-3-fluoropyridin-2-yl)methanol

Downstream raw materials:

(Z)-N-(5-(5-(5-chloro-3-fluoro-N'-hydroxypicolinimidamido)-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)benzamide

N-(5-(5-((6-chloroisoxazolo[4,5-b]pyridin-3-yl)amino)-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)benzamide

N-(3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-6-chloroisoxazolo[4,5-b]pyridin-3-amine

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