1-(aminomethyl)cyclopentanol hydrochloride

Base Information

• Chemical Name: 1-(aminomethyl)cyclopentanol hydrochloride
• CAS No.: 76066-27-8
• Molecular Formula: C6H14ClNO
• Molecular Weight: 151.636
• Hs Code.: 2922199090
• Mol file: 76066-27-8.mol

Synonyms:1-(aminomethyl)cyclopentanol hydrochloride;Cyclopentanol, 1-(aMinoMethyl)-, hydrochloride

Chemical Property of 1-(aminomethyl)cyclopentanol hydrochloride

Chemical Property:

• Melting Point: 190℃
• PSA: 46.25000
• LogP: 1.75250
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

1-(Aminomethyl)cyclopentanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(Aminomethyl)cyclopentanol Hydrochloride is used for preparation and inhibition of phenylethanolamine N-methyltransferase. It is also used for preparation of sulfonyl benzimidazole derivatives useful in treatment of diseases-mediated by CB2 receptor.

Technology Process of 1-(aminomethyl)cyclopentanol hydrochloride

There total 3 articles about 1-(aminomethyl)cyclopentanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-hydroxycyclopentanecarbonitrile (5117-85-1) → 1-(aminomethyl)cyclopentanol hydrochloride (76066-27-8)

Guidance literature:

1-hydroxycyclopentanecarbonitrile; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h; Reflux;

With hydrogenchloride; In 1,4-dioxane; tert-butyl methyl ether; at 20 ℃; for 0.5h;

Reference yield:

cyclopentanone (120-92-3) → 1-(aminomethyl)cyclopentanol hydrochloride (76066-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: zinc dibromide / 12 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux

2.2: 0.5 h / 20 °C

With lithium aluminium tetrahydride; zinc dibromide; In tetrahydrofuran;

Reference yield:

→ 1-(aminomethyl)cyclopentanol hydrochloride (76066-27-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃;

upstream raw materials:

cyclopentanone

1-hydroxycyclopentanecarbonitrile

Downstream raw materials:

1-{[(4-bromo-2-nitrophenyl)amino]methyl}cyclopentanol

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