[5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL

Base Information

• Chemical Name: [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL
• CAS No.: 343374-44-7
• Molecular Formula: C10H8ClNO2
• Molecular Weight: 209.632
• Hs Code.: 2934999090
• Mol file: 343374-44-7.mol

Synonyms:[5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL;5-(2-CHLOROPHENYL)-3-ISOXAZOLEMETHANOL

Chemical Property of [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL

Chemical Property:

• Boiling Point: 370.5±32.0 °C(Predicted)
• PKA: 12.96±0.10(Predicted)
• PSA: 46.26000
• Density: 1.339±0.06 g/cm3(Predicted)
• LogP: 2.48730

Purity/Quality:

97% ^*data from raw suppliers

[5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL

There total 3 articles about [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 5-(2-chlorophenyl)isoxazole-3-carboxylate → C10H8ClNO2 (343374-44-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.3390/molecules21121722

Reference yield:

ethyl 5-(2-chlorophenyl)isoxazole-3-carboxylate → C10H8ClNO2 (343374-44-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 3h; Cooling with ice;

DOI:10.1002/ardp.201100345

Reference yield:

4-(2-chloro-phenyl)-2,4-dioxo-butyric acid ethyl ester (338982-35-7) → C10H8ClNO2 (343374-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / ethanol / 3 h / Reflux

2: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; hydroxylamine hydrochloride; In ethanol;

DOI:10.1002/ardp.201100345

upstream raw materials:

4-(2-chloro-phenyl)-2,4-dioxo-butyric acid ethyl ester

Downstream raw materials:

2-amino-3-cyano-7-dimethylamino-4-(5-(2-chlorophenyl)-isoxazol-3-yl)-4H-chromene

3-chloromethyl-5-(2-chloro-phenyl)-isoxazole