(3AR,6AS)-2,2-DIMETHYLTETRAHYDRO-3AH-[1,3]DIOXOLO[4,5-C]PYRROLE

Base Information

• Chemical Name: (3AR,6AS)-2,2-DIMETHYLTETRAHYDRO-3AH-[1,3]DIOXOLO[4,5-C]PYRROLE
• CAS No.: 845269-67-2
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.186
• Mol file: 845269-67-2.mol

Synonyms:(3AR,6AS)-2,2-DIMETHYLTETRAHYDRO-3AH-[1,3]DIOXOLO[4,5-C]PYRROLE

Chemical Property of (3AR,6AS)-2,2-DIMETHYLTETRAHYDRO-3AH-[1,3]DIOXOLO[4,5-C]PYRROLE

Chemical Property:

• PSA: 30.49000
• LogP: 0.43850

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3AR,6AS)-2,2-DIMETHYLTETRAHYDRO-3AH-[1,3]DIOXOLO[4,5-C]PYRROLE

There total 13 articles about (3AR,6AS)-2,2-DIMETHYLTETRAHYDRO-3AH-[1,3]DIOXOLO[4,5-C]PYRROLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(3aR,6aS)-5-benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrole (151948-15-1,1028903-73-2) → (meso)-3,4-isopropylidenedioxy-2,5-pyrrolidine hydrotosylate (152139-64-5,845269-67-2)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; for 21h;

DOI:10.1002/chem.200304718

Reference yield: 94.0%

(3aR,6aS)-5-Benzyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole; compound with borane → (meso)-3,4-isopropylidenedioxy-2,5-pyrrolidine hydrotosylate (152139-64-5,845269-67-2)

Guidance literature:

palladium on activated charcoal; In methanol; at 20 ℃; for 12h;

DOI:10.1021/ol006969+

Reference yield: 89.0%

N-benzyl-(3aR,6aS)-tetrahydro-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyrrole → (meso)-3,4-isopropylidenedioxy-2,5-pyrrolidine hydrotosylate (152139-64-5,845269-67-2)

Guidance literature:

With hydrogenchloride; palladium-carbon; In methanol; diethyl ether;

upstream raw materials:

(3aR,6aS)-5-benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrole

meso 3,4-cis-isopropylidenedioxy-1-hydroxypyrrolidine

2,3-O-isopropylidene-L-erythrofuranose

((4R,5S)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol

Downstream raw materials:

4-(((3aR,6aS)-2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-5(4H)-yl)sulfonyl)benzonitrile

meso-3,4-isopropylidenedioxypyrrolidine hydrotosylate

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