1,5-Dioxaspiro[2.4]heptane

Base Information

• Chemical Name: 1,5-Dioxaspiro[2.4]heptane
• CAS No.: 185-61-5
• Molecular Formula: C5H8O2
• Molecular Weight: 100.117
• Hs Code.: 2932999099
• Mol file: 185-61-5.mol

Synonyms:1,5-Dioxaspiro[2.4]heptane

Chemical Property of 1,5-Dioxaspiro[2.4]heptane

Chemical Property:

• Boiling Point: 46-48 °C(Press: 14 Torr)
• PSA: 21.76000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 0.17570

Purity/Quality:

97% ^*data from raw suppliers

1,5-DIOXASPIRO[2.4]HEPTANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• General Description: 1,5-Dioxaspiro[2.4]heptane is a spirocyclic compound featuring a cyclopropane ring fused to a 1,3-dioxolane ring. It serves as a key structural motif in biologically active natural products and is a versatile intermediate in organic synthesis. 1,5-Dioxaspiro[2.4]heptane can be synthesized from 2,3-dichloroprop-1-ene via lithiation and subsequent cyclization, with potential further functionalization, such as oxidation to lactones, highlighting its utility in synthetic chemistry.

Refernces

Synthesis of substituted 1,5-dioxaspiro[2.4]heptanes from 2,3-dichloroprop-1-ene

10.1002/1522-2675(200210)85:10<3262::AID-HLCA3262>3.0.CO;2-R

The study focuses on the synthesis of substituted 1,5-dioxaspiro[2.4]heptanes using 2,3-dichloroprop-1-ene as the starting material. The key steps involve a 4,4'-di(tert-butyl)biphenyl (DTBB)-catalyzed lithiation of 2,3-dichloroprop-1-ene in the presence of various symmetrically substituted ketones, yielding methylene-substituted diols. These diols are then treated with NaH and I2 to form 1,5-dioxaspiro[2.4]heptanes. The synthesized compounds can be further oxidized to lactones using RuO2 and NaIO4. The study demonstrates a straightforward and efficient method for synthesizing these compounds, which are important structural units in many biologically active natural products and versatile intermediates in organic synthesis.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 185-61-5 1,5-Dioxaspiro[2.4]heptane

Send

Send

Metric Ton KG G Pound L ML

Send

Send