(S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline

Base Information

Chemical Name:(S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline
CAS No.:1065481-28-8
Molecular Formula:C11H8ClFN4
Molecular Weight:250.663
Hs Code.:
Mol file:1065481-28-8.mol

Synonyms:(S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline

Suppliers and Price of (S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
(S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline 95%
1g
$ 849.00

Matrix Scientific
(S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline 95%
500mg
$ 510.00

Matrix Scientific
(S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline 95%
250mg
$ 319.00

Alichem
(S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline
500mg
$ 980.00

AK Scientific
(S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline
250mg
$ 480.00

Total 4 raw suppliers

Chemical Property of (S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline

Chemical Property:

PSA：62.64000
LogP:3.85136

Purity/Quality:

98%, ^*data from raw suppliers

(S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline

There total 7 articles about (S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1065481-27-7
(R)-1-(2-chloro-8-fluoroquinolin-3-yl)ethanol

: 1065481-28-8
(S)-3-(1-azidoethyl)-2-chloro-8-fluoro-quinoline

Guidance literature:: With di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 348-54-9
2-Fluoroaniline

: 1065481-28-8
(S)-3-(1-azidoethyl)-2-chloro-8-fluoro-quinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / water; acetone / 3 h / 0 °C

2.1: aluminum (III) chloride / chlorobenzene / 3 h / 125 °C

3.1: trichlorophosphate / 2 h / 125 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C

4.2: 0.5 h

5.1: manganese(IV) oxide / toluene / 2 h / Heating / reflux

6.1: B-chlorodiisopinocampheylborane / tetrahydrofuran / 5 h / -55 - 10 °C

6.2: 1 h / 20 °C

7.1: di-isopropyl azodicarboxylate; diphenyl phosphoryl azide / tetrahydrofuran / 0 - 20 °C

With manganese(IV) oxide; aluminum (III) chloride; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; potassium carbonate; B-chlorodiisopinocampheylborane; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; water; chlorobenzene; acetone; toluene;

Reference yield:

: 71738-83-5
8-fluoroquinolin-2(1H)-one

: 1065481-28-8
(S)-3-(1-azidoethyl)-2-chloro-8-fluoro-quinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 2 h / 125 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C

2.2: 0.5 h

3.1: manganese(IV) oxide / toluene / 2 h / Heating / reflux

4.1: B-chlorodiisopinocampheylborane / tetrahydrofuran / 5 h / -55 - 10 °C

4.2: 1 h / 20 °C

5.1: di-isopropyl azodicarboxylate; diphenyl phosphoryl azide / tetrahydrofuran / 0 - 20 °C

With manganese(IV) oxide; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; B-chlorodiisopinocampheylborane; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; toluene;