4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
CAS No.:1121596-52-8
Molecular Formula:C16H21F3N2O2
Molecular Weight:330.3453496
Hs Code.:
Mol file:1121596-52-8.mol

Synonyms:4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester;tert-butyl 4-(2-(trifluoromethyl)phenyl)piperazine-1-carboxylate

Suppliers and Price of 4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Density:1.208±0.06 g/cm3 (20 ºC 760 Torr)

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Technology Process of 4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

There total 2 articles about 4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 392-83-6
o-trifluoromethylphenyl bromide

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1121596-52-8
tert-butyl 4-(2-(trifluoromethyl)-phenyl)piperazine-1-carboxylate

Guidance literature:: With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 110 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b00423

Reference yield: 50.0%

: 77278-40-1
tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate

: 98-08-8
α,α,α-trifluorotoluene

: tert-butyl 4-(3-(trifluoromethyl)phenyl)piperazine-1-carboxylate

: 4-(4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1121596-52-8
tert-butyl 4-(2-(trifluoromethyl)-phenyl)piperazine-1-carboxylate

Guidance literature:: α,α,α-trifluorotoluene; With 1.1C₉H₁₈N^(1-)*C₄H₁₀Zn*2Li⁽¹⁺⁾; In tetrahydrofuran; hexane; at 20 ℃; for 1h; Inert atmosphere; Schlenk technique;

tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate; With copper(II) 2-ethylhexanoate; In tetrahydrofuran; hexane; at 20 ℃; for 24h; regioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1021/jacs.7b07661

Reference yield:

: 1121596-52-8
tert-butyl 4-(2-(trifluoromethyl)-phenyl)piperazine-1-carboxylate

: C₂₂H₁₉F₃N₆

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 120 °C

With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2016.02.050