Ethyl 5-aMino-1H-pyrazole-4-carboxylate

Base Information

• Chemical Name: Ethyl 5-aMino-1H-pyrazole-4-carboxylate
• CAS No.: 1260243-04-6
• Molecular Formula: C₆H₉N₃O₂
• Molecular Weight: 155.156
• Mol file: 1260243-04-6.mol

Synonyms:1H-Pyrazole-4-carboxylic acid, 3-amino-, ethyl ester; 1H-Pyrazole-4-carboxylic acid, 5-amino-, ethyl ester; Ethyl 3-amino-1H-pyrazole-4-carboxylate; Ethyl 5-amino-1H-pyrazole-4-carboxylate; Ethyl-5-amino-1H-pyrazol-4-carboxylat; 5-Amino-1H-pyrazole-4-carboxylic acid ethyl ester; Ethyl 5-Amino-1H-4-Pyrazolecarboxylate

Chemical Property of Ethyl 5-aMino-1H-pyrazole-4-carboxylate

Chemical Property:

• Vapor Pressure: 4.79E-05mmHg at 25°C
• Boiling Point: 349.2°C at 760 mmHg
• Flash Point: 165°C
• PSA: 81.00000
• Density: 1.318g/cm³
• LogP: 0.74980
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-amino-1H-pyrazole-4-carboxylate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 5-aMino-1H-pyrazole-4-carboxylate

There total 10 articles about Ethyl 5-aMino-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-cyano-3-ethoxyacrylic acid ethyl ester (94-05-3,42466-69-3) → ethyl 5-amino-1H-pyrazole-4-carboxylate (1260243-04-6,6994-25-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 75 ℃; for 2h;

DOI:10.1016/j.bmcl.2007.05.028

Reference yield: 85.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + ethyl 2-cyanoacetate (105-56-6) → ethyl 5-amino-1H-pyrazole-4-carboxylate (1260243-04-6,6994-25-8)

Guidance literature:

N,N-dimethyl-formamide dimethyl acetal; ethyl 2-cyanoacetate; With acetic acid; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

With hydrazine hydrate; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

DOI:10.1007/s00706-016-1723-9

Reference yield: 70.0%

ethyl (Z)-2-cyano-3-methoxyacrylate (42466-68-2) → ethyl 5-amino-1H-pyrazole-4-carboxylate (1260243-04-6,6994-25-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 25 - 30 ℃; for 2h; Reflux; Inert atmosphere;

DOI:10.3184/174751917X14894997017694

upstream raw materials:

ethyl (ethoxymethylene)cyanoacetate

2-cyano-3-ethoxyacrylic acid ethyl ester

ethyl 2-cyanoacetate

ethyl (ethoxymethylene)cyanoacetate

Downstream raw materials:

(5,6,7,8-Tetrahydro-1H-pyrazolo[3,4-b]quinolin-4-yl)-p-tolyl-amine

(4-Fluoro-phenyl)-(5,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-4-yl)-amine

(4-Chloro-phenyl)-(5,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-4-yl)-amine

4-Phenylamino-5,6,7,8-tetrahydro-1H-pyrazolo<3,4-b>quinoline