Morpholine (3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylate

Base Information

• Chemical Name: Morpholine (3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylate
• CAS No.: 1103738-20-0
• Molecular Formula: C12H21NO7
• Molecular Weight: 291.3
• Mol file: 1103738-20-0.mol

Synonyms:Morpholine (3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylate;morpholine salt

Chemical Property of Morpholine (3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylate

Chemical Property:

• PSA: 106.48000
• LogP: -0.75670

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Morpholine (3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylate

There total 5 articles about Morpholine (3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

morpholine (110-91-8,99108-56-2) + 1,2-O-isopropylidene-α-L-xylofuranose (114861-22-2) → morpholine (3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylic acid (1103738-20-0)

Guidance literature:

1,2-O-isopropylidene-α-L-xylofuranose; With sodium hypochlorite; sodium chlorite; dipotassium hydrogenphosphate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In water; acetonitrile; at 15 - 25 ℃; Industry scale;

morpholine; In acetonitrile; at 0 - 5 ℃; Inert atmosphere; Industry scale;

Reference yield:

morpholine (110-91-8,99108-56-2) + (3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxolane-5-carboxylic acid (1103738-17-5) → morpholine (3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylic acid (1103738-20-0)

Guidance literature:

In acetonitrile; Industry scale;

Reference yield:

L-xylose (609-06-3) → morpholine (3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylic acid (1103738-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium sulfate; sulfuric acid / 17.25 h / 20 - 24 °C / Industry scale

1.2: 6 h / 20 °C / pH 2

2.1: dipotassium hydrogenphosphate; sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile; water / 15 - 25 °C / Industry scale

2.2: 0 - 5 °C / Inert atmosphere; Industry scale

With sodium hypochlorite; sodium chlorite; dipotassium hydrogenphosphate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sulfuric acid; magnesium sulfate; In water; acetonitrile;

upstream raw materials:

morpholine

(3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxolane-5-carboxylic acid

1,2-O-isopropylidene-α-L-xylofuranose

L-xylose

Downstream raw materials:

((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholin-4-yl)methanone

(4-chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuran[2,3-d][1,3]dioxolan-5-yl)methanone

Refernces

• 1、 -. "Solid forms of (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol and methods of their use". Page/Page column 7. . Retrieved 2011/06/26.
• 2、 -. "METHODS AND COMPOUNDS USEFUL FOR THE PREPARATION OF SODIUM GLUCOSE CO-TRANSPORTER 2 INHIBITORS". Page/Page column 8. . Retrieved 2009/02/11.