Technology Process of 6-Bromo-2,3,4,5-tetrahydro-1H-1-benzazepine
There total 2 articles about 6-Bromo-2,3,4,5-tetrahydro-1H-1-benzazepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-5-bromo-3,4-dihydronaphthalen-1(2H)-one oxime;
With
diisobutylaluminium hydride;
In
hexane; dichloromethane;
at -10 - 20 ℃;
for 2h;
Inert atmosphere;
With
sodium fluoride;
In
hexane; dichloromethane; water;
at -10 - 0 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2019.126929
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydroxylamine hydrochloride / pyridine / 1 h / 20 °C
2.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -10 - 20 °C / Inert atmosphere
2.2: 0.5 h / 0 °C
With
hydroxylamine hydrochloride; diisobutylaluminium hydride;
In
pyridine; hexane; dichloromethane;
