tert-butyl 4-(2-chloro-5-(trifluoromethyl)phenyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-chloro-5-(trifluoromethyl)phenyl)piperazine-1-carboxylate
CAS No.:1121600-05-2
Molecular Formula:C₁₆H₂₀ClF₃N₂O₂
Molecular Weight:364.795
Hs Code.:

Synonyms:tert-butyl 4-(2-chloro-5-(trifluoromethyl)phenyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-chloro-5-(trifluoromethyl)phenyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(2-chloro-5-(trifluoromethyl)phenyl)piperazine-1-carboxylate

There total 1 articles about tert-butyl 4-(2-chloro-5-(trifluoromethyl)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 454-78-4
3-bromo-4-chlorobenzotrifluoride

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1121600-05-2
tert-butyl 4-[2-chloro-5-(trifluoromethyl)phenyl]piperazine-1-carboxylate

Guidance literature:: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 120 ℃; Inert atmosphere;

Reference yield:

: 1121600-05-2
tert-butyl 4-[2-chloro-5-(trifluoromethyl)phenyl]piperazine-1-carboxylate

: 1-[2-chloro-5-(trifluoromethyl)phenyl]piperazine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 1121600-05-2
tert-butyl 4-[2-chloro-5-(trifluoromethyl)phenyl]piperazine-1-carboxylate

: 3-{4-[2-chloro-5-(trifluoromethyl)phenyl]piperazin-1-yl}isoxazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: sodium carbonate / butan-1-ol / 16 h / 110 °C

3: 1H-imidazole; iodine / toluene / 15 h / Reflux

With 1H-imidazole; hydrogenchloride; iodine; sodium carbonate; In 1,4-dioxane; toluene; butan-1-ol;