N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

Base Information

Chemical Name:N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
CAS No.:1210608-43-7
Molecular Formula:C24H23F3N4O
Molecular Weight:440.468
Hs Code.:
Mol file:1210608-43-7.mol

Synonyms:N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide;PIM447 (LGH447);PIM447;PIM447 (LGH447) Free Base

Suppliers and Price of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PIM447
0.25mg
$ 185.00

TRC
PIM447
2.5mg
$ 1025.00

CSNpharm
PIM-447
10mg
$ 480.00

Total 34 raw suppliers

Chemical Property of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

Chemical Property:

Appearance/Colour:Solid powder
Boiling Point:493.7±45.0 °C(Predicted)
PKA:1.35±0.70(Predicted)
PSA：80.90000
Density:1.290±0.06 g/cm3(Predicted)
LogP:5.81740

Purity/Quality:

97% ^*data from raw suppliers

PIM447 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses PIM kinases promote growth and survival of tumor cells and are expressed in a wide variety of human cancers. These kinases are potential therapeutic targets. PIM447 is a PIM kinase inhibitor.

Technology Process of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

There total 6 articles about N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl (1S,3R,5S)-3-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylcyclohexylcarbamate

: 1210608-43-7
N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 17 h / 20 °C

2: sodium carbonate / ethyl acetate

With hydrogenchloride; sodium carbonate; In 1,4-dioxane; ethyl acetate;
DOI:10.1021/acs.jmedchem.5b01275

Reference yield:

: C₂₄H₂₃F₃N₄O*2ClH

: 1210608-43-7
N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide

Guidance literature:: With sodium carbonate; In ethyl acetate;
DOI:10.1021/acs.jmedchem.5b01275

Reference yield:

: C₁₂H₁₉N₃

: 1210608-43-7
N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: Inert atmosphere

2: Chiralpak OJ / ethanol; methanol; n-heptane / Resolution of racemate

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 12 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 17 h / 20 °C

5: sodium carbonate / ethyl acetate

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; ethanol; n-heptane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01275