Deplancheine

Base Information

Chemical Name:Deplancheine
CAS No.:74559-69-6
Molecular Formula:C₁₇H₂₀N₂
Molecular Weight:252.359
Hs Code.:
Mol file:74559-69-6.mol

Synonyms:(12bR)-1,2,3,4,6,7,12,12b-Octahydro-3-[(E)-ethylidene]indolo[2,3-a]quinolizine;(3E)-3-Ethylidene-1,2,3,4,6,7,12,12bα-octahydroindolo[2,3-a]quinolizine;(R)-Deplancheine;1,2,3,4,6,7,12,12bα-Octahydro-3-[(E)-ethylidene]indolo[2,3-a]quinolizine

Suppliers and Price of Deplancheine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Deplancheine

Chemical Property:

Melting Point:139 - 140 °C
PSA：19.03000
LogP:3.74510

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Deplancheine

There total 14 articles about Deplancheine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 827609-61-0
(12bR)-(E)-3-ethylidene-1,2,3,6,7,12b-hexahydroindolo[2,3-a]quinolizin-4(12H)-one

: 74559-69-6
(R)-(+)-deplancheine

Guidance literature:: With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol9011772

Reference yield:

: 778591-55-2
(6S,12bR)-1,2,3,6,7,12b-hexahydro-6-(hydroxymethyl)indolo[2,3-a]quinolizin-4(12H)-one

: 74559-69-6
(R)-(+)-deplancheine

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1-hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide / dimethylsulfoxide / 24 h / 20 °C

2.1: Et₃N; 4-(dimethylamino)pyridine / tetrahydrofuran / 4 h / 20 °C

3.1: NaClO₂; NaH₂PO₄; 1-methyl-1-cyclohexene / H₂O; acetonitrile; 2-methyl-propan-2-ol / 18 h / 20 °C

4.1: tributylphosphane / CH₂Cl₂ / 18 h / 20 °C

5.1: nBu₃SnH; azobis(isobutyronitrile) / toluene / 2 h / 80 °C

6.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C

7.1: triethylamine / CH₂Cl₂ / 3.33 h / -40 - 20 °C

8.1: 1,5-diazabicyclo[4.3.0]non-5-ene / tetrahydrofuran; CH₂Cl₂ / 16 h / 20 °C

9.1: 63 percent / tetrabutylammonium fluoride / tetrahydrofuran / 9 h / Heating

10.1: trimethyoxonium tetrafluoroborate; 2,6-di-tert-butylpyridine / CH₂Cl₂ / 21 h / 20 °C

10.2: 77 percent / sodium borohydride / methanol; CH₂Cl₂ / 0.5 h / 0 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2,6-di-tert-butyl-pyridine; 1-methylcyclohex-1-ene; 2,2'-azobis(isobutyronitrile); tributylphosphine; DBN; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; trimethoxonium tetrafluoroborate; triethylamine; diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1002/ejoc.200500412

Reference yield:

: 827609-55-2
(6S,12bR)-4-oxo-1,2,3,4,6,7,12,12b-octahydropyrido[2,1-a]β-carboline-6-carbaldehyde

: 74559-69-6
(R)-(+)-deplancheine

Guidance literature:: Multi-step reaction with 9 steps

1.1: Et₃N; 4-(dimethylamino)pyridine / tetrahydrofuran / 4 h / 20 °C

2.1: NaClO₂; NaH₂PO₄; 1-methyl-1-cyclohexene / H₂O; acetonitrile; 2-methyl-propan-2-ol / 18 h / 20 °C

3.1: tributylphosphane / CH₂Cl₂ / 18 h / 20 °C

4.1: nBu₃SnH; azobis(isobutyronitrile) / toluene / 2 h / 80 °C

5.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C

6.1: triethylamine / CH₂Cl₂ / 3.33 h / -40 - 20 °C

7.1: 1,5-diazabicyclo[4.3.0]non-5-ene / tetrahydrofuran; CH₂Cl₂ / 16 h / 20 °C

8.1: 63 percent / tetrabutylammonium fluoride / tetrahydrofuran / 9 h / Heating

9.1: trimethyoxonium tetrafluoroborate; 2,6-di-tert-butylpyridine / CH₂Cl₂ / 21 h / 20 °C

9.2: 77 percent / sodium borohydride / methanol; CH₂Cl₂ / 0.5 h / 0 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2,6-di-tert-butyl-pyridine; 1-methylcyclohex-1-ene; 2,2'-azobis(isobutyronitrile); tributylphosphine; DBN; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; trimethoxonium tetrafluoroborate; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1002/ejoc.200500412