5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT

Base Information

• Chemical Name: 5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT
• CAS No.: 1047953-91-2
• Molecular Formula: C19H17Cl3N4O3
• Molecular Weight: 455.728
• Mol file: 1047953-91-2.mol

Synonyms:5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT;TELOMERASE INHIBITOR II, SODIUM SALT;MI-2;MI 2 (MALT1 inhibitor);2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenyl]-Acetamide;ATP-dependent helicase CHD4;CHD-4;Mi-2 autoantigen 218 kDa protein

Chemical Property of 5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT

Chemical Property:

• PSA: 78.27000
• LogP: 4.51660
• Storage Temp.: -20°C

Purity/Quality:

97% ^*data from raw suppliers

MI 2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: MALT1 inhibitor binds directly to MALT1 and irreversibly suppresses protease function. It decreases NF-κB activity induced by MALT1 and inhibits cell proliferation and MALT1-mediated cleavage activity.

Technology Process of 5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT

There total 6 articles about 5'-D(ATGAAAATCAGGGTTAGG)-3', SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)aniline + chloroacetic acid (79-11-8) → 2-chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide (1047953-91-2)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.bmc.2018.04.059

Reference yield:

3,4-dichlorbenzoic acid (51-44-5) → 2-chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide (1047953-91-2)

Guidance literature:

Multi-step reaction with 6 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C

2: acetone / 60 °C

3: acetone / 60 °C

4: ethanol / 24 h / 90 °C

5: acetic acid; zinc / methanol / 12 h / 20 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C

With oxalyl dichloride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; zinc; In methanol; ethanol; dichloromethane; acetone;

DOI:10.1016/j.bmc.2018.04.059

Reference yield:

3,4-dichlorobenzoyl isothiocyanate (6954-85-4) → 2-chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide (1047953-91-2)

Guidance literature:

Multi-step reaction with 4 steps

1: acetone / 60 °C

2: ethanol / 24 h / 90 °C

3: acetic acid; zinc / methanol / 12 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C

With acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In methanol; ethanol; dichloromethane; acetone;

DOI:10.1016/j.bmc.2018.04.059

upstream raw materials:

3,4-dichlorbenzoic acid

chloroacetic acid

3,4-dichlorobenzoyl isothiocyanate

3,4-dichlorobenzoyl chloride