(3r,5r,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid

Base Information

Chemical Name:(3r,5r,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid
CAS No.:1094100-06-7
Molecular Formula:C22H28FN3O6S
Molecular Weight:481.545
Hs Code.:
UNII:K637T66PWQ
Nikkaji Number:J3.026.202F
Wikidata:Q63392169

Synonyms:1094100-06-7;(3r,5r,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid;Rosuvastatin diastereomers;(3R,5R)-Rosuvastatin;K637T66PWQ;(3R,5R)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid;(3RS,5RS,6E)-7-(4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid;UNII-K637T66PWQ;SCHEMBL41433;MLS003876821;SCHEMBL6427206;Rosuvastatin diastereomers [USP];HY-17504C;Rosuvastatin calcium impurity B [EP];AKOS015896473;AM84432;SMR002533185;CS-0112376;EN300-128503;F19506;ROSUVASTATIN DIASTEREOMER [USP IMPURITY];EN300-24772312;Q63392169;ROSUVASTATIN CALCIUM IMPURITY B [EP IMPURITY];Z1614456947;(3R,5R)-7-[2-[Methyl(methylsulfonyl)amino]-4-isopropyl-6-(4-fluorophenyl)pyrimidine-5-yl]-3,5-dihydroxy-6-heptenoic acid;(3R,5R,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid

Suppliers and Price of (3r,5r,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
(3R,5R)-Rosuvastatin sodium salt
25 mg
$ 3125.00

Biosynth Carbosynth
(3R,5R)-Rosuvastatin sodium salt
10 mg
$ 1850.00

Biosynth Carbosynth
(3R,5R)-Rosuvastatin sodium salt
2 mg
$ 1600.00

Biosynth Carbosynth
(3R,5R)-Rosuvastatin sodium salt
5 mg
$ 1200.00

Biosynth Carbosynth
(3R,5R)-Rosuvastatin sodium salt
1 mg
$ 500.00

Total 11 raw suppliers

Chemical Property of (3r,5r,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid

Chemical Property:

Melting Point:59-61°C
PSA：149.30000
Density:1.368
LogP:3.48250
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
XLogP3:1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:10
Exact Mass:481.16828496
Heavy Atom Count:33
Complexity:767

Purity/Quality:

99%, ^*data from raw suppliers

(3R,5R)-Rosuvastatin sodium salt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C
Isomeric SMILES:CC(C)C1=NC(=NC(=C1/C=C/[C@@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C
Uses Rosuvastatin Anti Isomer is an impurity and a degradation product of Rosuvastatin. Rosuvastatin is an antilipemic. (3R,5R)-Rosuvastatin is an enantiomer of Rosuvastatin (R700500) used for treatment, prevention and combination therapy of lipid-related disorders.

Technology Process of (3r,5r,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid

There total 5 articles about (3r,5r,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₆FN₃O₆S

: 1094100-06-7
(E)-(3R,5R)-7-[4-(4-fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid

Guidance literature:: With hydrogenchloride; sodium hydroxide; In ethanol; water; at 45 - 50 ℃;

Reference yield:

: 289042-12-2,1378943-63-5
2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester

: 1094100-06-7
(E)-(3R,5R)-7-[4-(4-fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / water; acetonitrile / 3 h / 35 - 40 °C

2: manganese(IV) oxide / 20 h / Reflux

3: sodium tetrahydroborate; methanol / 2 h / 0 - 25 °C

4: sodium hydroxide / acetonitrile / 2 h / 0 - 10 °C

5: sodium hydroxide; hydrogenchloride / water; ethanol / 45 - 50 °C

With hydrogenchloride; methanol; manganese(IV) oxide; sodium tetrahydroborate; sodium hydroxide; In ethanol; water; acetonitrile;

Reference yield:

: 355806-00-7
rosuvastatin tert-butyl ester

: 1094100-06-7
(E)-(3R,5R)-7-[4-(4-fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: manganese(IV) oxide / 20 h / Reflux

2: sodium tetrahydroborate; methanol / 2 h / 0 - 25 °C

3: sodium hydroxide / acetonitrile / 2 h / 0 - 10 °C

4: sodium hydroxide; hydrogenchloride / water; ethanol / 45 - 50 °C

With hydrogenchloride; methanol; manganese(IV) oxide; sodium tetrahydroborate; sodium hydroxide; In ethanol; water; acetonitrile;