2-Amino-2-cyclopropylpropanenitrile

Base Information

• Chemical Name: 2-Amino-2-cyclopropylpropanenitrile
• CAS No.: 37024-73-0
• Molecular Formula: C6H11N2+
• Molecular Weight: 110.159
• Hs Code.: 2926909090
• European Community (EC) Number: 838-200-2
• DSSTox Substance ID: DTXSID30396468
• Nikkaji Number: J23.521K
• Mol file: 37024-73-0.mol

Synonyms:2-amino-2-cyclopropylpropanenitrile;37024-73-0;SCHEMBL77175;DTXSID30396468;VGFGZZVMDIZSTI-UHFFFAOYSA-N;2-Amino-2-cyclopropylpropiononitrile;MFCD04621701;AKOS000118708;BS-12795;CS-0377577;EN300-06776;ETHYL6-(3-HYDROXY-3-METHYLBUT-1-YNYL)NICOTINATE

Chemical Property of 2-Amino-2-cyclopropylpropanenitrile

Chemical Property:

• Vapor Pressure: 0.402mmHg at 25°C
• Boiling Point: 196.3°C at 760 mmHg
• Flash Point: 72.5°C
• PSA: 49.81000
• LogP: 1.33768
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 110.084398327
• Heavy Atom Count: 8
• Complexity: 140

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-2-cyclopropylpropanenitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C#N)(C1CC1)N

Technology Process of 2-Amino-2-cyclopropylpropanenitrile

There total 5 articles about 2-Amino-2-cyclopropylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

potassium cyanide + Cyclopropyl methyl ketone (765-43-5) → 2-amino-2-cyclopropyl-propanenitrile (37024-73-0)

Guidance literature:

With ammonium hydroxide; ammonium chloride; In water; at 4 - 25 ℃;

DOI:10.1039/b719675j

Reference yield: 81.0%

Cyclopropyl methyl ketone (765-43-5) + potassium cyanide (151-50-8) → 2-amino-2-cyclopropyl-propanenitrile (37024-73-0)

Guidance literature:

With ammonium hydroxide; ammonium chloride; In water; at 20 ℃; for 5h;

DOI:10.1016/S0040-4020(99)00379-8

Reference yield: 43.0%

2-cyclopropyl-2-hydroxy-propionitrile (4111-11-9) → 2-amino-2-cyclopropyl-propanenitrile (37024-73-0)

Guidance literature:

With titanium(IV) isopropylate; ammonia; benzoic acid; In methanol; tert-butyl methyl ether; for 18h; Heating;

DOI:10.1021/acs.orglett.9b03194

upstream raw materials:

Cyclopropyl methyl ketone

potassium cyanide

2-cyclopropyl-2-hydroxy-propionitrile

Downstream raw materials:

2-cyclopropyl-2-(N-benzyl)methanesulfonamidopropionitrile

2-amino-5-chloro-N-(cyano-cyclopropyl-methyl-methyl)-3-methyl-benzamide

C₁₈H₁₈ClN₃OS

5-cyclopropyl-5-methylimidazolidine-2,4-dione