5-(4-methylpiperazin-1-yl)picolinic acid

Base Information

• Chemical Name: 5-(4-methylpiperazin-1-yl)picolinic acid
• CAS No.: 892501-96-1
• Molecular Formula: C₁₁H₁₅N₃O₂
• Molecular Weight: 221.259
• Mol file: 892501-96-1.mol

Synonyms:5-(4-methylpiperazin-1-yl)picolinic acid

Chemical Property of 5-(4-methylpiperazin-1-yl)picolinic acid

Chemical Property:

• Boiling Point: 420.2±45.0 °C(Predicted)
• PKA: 1.46±0.50(Predicted)
• Density: 1.239±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-(4-Methylpiperazin-1-yl)picolinicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-methylpiperazin-1-yl)picolinic acid

There total 2 articles about 5-(4-methylpiperazin-1-yl)picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methyl 5-(4-methylpiperazin-1-yl)pyridine-2-carboxylate (1035270-92-8) → 5-(4-methylpiperazin-1-yl)pyridine-2-carboxylic acid (892501-96-1)

Guidance literature:

With lithium hydroxide; In methanol; water; at 23 ℃; for 16h;

Reference yield:

→ 5-(4-methylpiperazin-1-yl)pyridine-2-carboxylic acid (892501-96-1)

Guidance literature:

Reference yield: 92.2%

tert-butyl 2-amino-4-(furan-3-yl)phenylcarbamate (335255-35-1) + 5-(4-methylpiperazin-1-yl)pyridine-2-carboxylic acid (892501-96-1) → tert-butyl 4-(furan-3-yl)-2-(5-(4-methylpiperazin-1-yl)picolinamido)phenylcarbamate

Guidance literature:

5-(4-methylpiperazin-1-yl)pyridine-2-carboxylic acid; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

tert-butyl 2-amino-4-(furan-3-yl)phenylcarbamate; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

methyl 5-(4-methylpiperazin-1-yl)pyridine-2-carboxylate

Downstream raw materials:

N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(4-methylpiperazin-1-yl)picolinamide

Refernces

• 1、 -. "AZOLYL UREA COMPOUNDS AND METHODS OF USE THEREOF". Page/Page column 111. . Retrieved 2011/12/14.