4,6-dichloro-5-(2-methoxy-phenoxy)-2-pyrazin-2-yl-pyrimidine

Base Information

Chemical Name:4,6-dichloro-5-(2-methoxy-phenoxy)-2-pyrazin-2-yl-pyrimidine
CAS No.:473537-04-1
Molecular Formula:C₁₅H₁₀Cl₂N₄O₂
Molecular Weight:349.176
Hs Code.:
Mol file:473537-04-1.mol

Synonyms:4,6-dichloro-5-(2-methoxy-phenoxy)-2-pyrazin-2-yl-pyrimidine

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Chemical Property of 4,6-dichloro-5-(2-methoxy-phenoxy)-2-pyrazin-2-yl-pyrimidine

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Technology Process of 4,6-dichloro-5-(2-methoxy-phenoxy)-2-pyrazin-2-yl-pyrimidine

There total 3 articles about 4,6-dichloro-5-(2-methoxy-phenoxy)-2-pyrazin-2-yl-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 473537-03-0
5-(2-methoxy-phenoxy)-2-pyrazin-2-yl-pyrimidine-4,6-diol

: 473537-04-1
4,6-dichloro-5-(2-methoxy-phenoxy)-2-pyrazin-2-yl-pyrimidine

Guidance literature:: With N,N-dimethyl-aniline; trichlorophosphate; at 120 ℃;
DOI:10.1016/S0960-894X(02)01084-3

Reference yield:

: 1878-85-9
(2-methoxyphenoxy)acetic acid

: 473537-04-1
4,6-dichloro-5-(2-methoxy-phenoxy)-2-pyrazin-2-yl-pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 3 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C

2.2: 24 h / 20 - 32 °C

3.1: sodium / methanol / 18 h / 0 - 20 °C

3.2: 4 h / 20 °C

4.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C

With thionyl chloride; sodium; sodium hydride; trichlorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-aniline; mineral oil;
DOI:10.1021/jm3009103

Reference yield:

: 150726-89-9
(2-methoxyphenoxy)-malonic acid dimethyl ester

: 473537-04-1
4,6-dichloro-5-(2-methoxy-phenoxy)-2-pyrazin-2-yl-pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium / methanol / 18 h / 0 - 20 °C

1.2: 4 h / 20 °C

2.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C

With sodium; trichlorophosphate; In methanol; N,N-dimethyl-aniline;
DOI:10.1021/jm3009103