6-(Trifluoromethyl)picolinamide

Base Information

Chemical Name:6-(Trifluoromethyl)picolinamide
CAS No.:22245-84-7
Molecular Formula:C7H5F3N2O
Molecular Weight:190.1226096
Hs Code.:
DSSTox Substance ID:DTXSID40392870
Wikidata:Q82191342

Synonyms:6-(Trifluoromethyl)picolinamide;22245-84-7;6-(trifluoromethyl)pyridine-2-carboxamide;SCHEMBL2826285;DTXSID40392870;XSMRRJXIDVNINP-UHFFFAOYSA-N;XAA24584;MFCD02180820;BS-16097;CS-0136720;FT-0761620;D82473;EN300-3030360

Suppliers and Price of 6-(Trifluoromethyl)picolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 6-(Trifluoromethyl)picolinamide

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:190.03539727
Heavy Atom Count:13
Complexity:204

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC(=C1)C(F)(F)F)C(=O)N

Technology Process of 6-(Trifluoromethyl)picolinamide

There total 2 articles about 6-(Trifluoromethyl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 6-(trifluoromethyl)pyridine-2-carbonyl chloride

: 22245-84-7
6-(trifluoromethyl)pyridine-2-carboxamide

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; at 0 - 25 ℃; for 1h; Inert atmosphere;

Reference yield:

: 131747-42-7
6-(trifluoromethyl)pyridine-2-carboxylic acid

: 22245-84-7
6-(trifluoromethyl)pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 25 °C / Inert atmosphere

2: ammonium hydroxide / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere

With ammonium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield: 99.0%

: 22245-84-7
6-(trifluoromethyl)pyridine-2-carboxamide

: methyl 6-bromo-2-(4-hydroxycyclohexyl)benzo[d]thiazole-5-carboxylate

: methyl 2-(4-hydroxycyclohexyl)-6-[[6-(trifluoromethyl)pyridine-2-carbonyl]amino]-1,3-benzothiazole-5-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 6h; Inert atmosphere;