4-Bromo-3',4'-difluorobenzophenone

Base Information

• Chemical Name: 4-Bromo-3',4'-difluorobenzophenone
• CAS No.: 844878-99-5
• Molecular Formula: C13H7BrF2O
• Molecular Weight: 297.099
• Hs Code.: 2914700090
• DSSTox Substance ID: DTXSID90373634
• Wikidata: Q82161889
• Mol file: 844878-99-5.mol

Synonyms:4-Bromo-3',4'-difluorobenzophenone;844878-99-5;(4-bromophenyl)-(3,4-difluorophenyl)methanone;(4-bromophenyl)(3,4-difluorophenyl)methanone;DTXSID90373634;MFCD06201445;AKOS009338180;A840814;(4-Bromo-phenyl)-(3,4-difluoro-phenyl)-methanone

Chemical Property of 4-Bromo-3',4'-difluorobenzophenone

Chemical Property:

• Vapor Pressure: 1.59E-05mmHg at 25°C
• Boiling Point: 365.3°C at 760 mmHg
• Flash Point: 174.7°C
• PSA: 17.07000
• Density: 1.546g/cm³
• LogP: 3.95830
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 295.96483
• Heavy Atom Count: 17
• Complexity: 277

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-3',4'-difluorobenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)C2=CC(=C(C=C2)F)F)Br

Technology Process of 4-Bromo-3',4'-difluorobenzophenone

There total 5 articles about 4-Bromo-3',4'-difluorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,4-bromoiodobenzene (589-87-7) + N,N-Boc2-3,4-difluorobenzamide → (4-bromophenyl)-(3,4-difluorophenyl)-methanone (844878-99-5)

Guidance literature:

1,4-bromoiodobenzene; With TurboGrignard; In tetrahydrofuran; at -20 ℃; for 3h; Inert atmosphere; Schlenk technique;

N,N-Boc₂-3,4-difluorobenzamide; In tetrahydrofuran; at -20 - 20 ℃; for 2.5h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201904678

Reference yield:

(4-bromophenyl)-(3,4-difluorophenyl)-methanol (1272202-25-1) → (4-bromophenyl)-(3,4-difluorophenyl)-methanone (844878-99-5)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; at 60 ℃;

DOI:10.1016/j.ejmech.2011.09.004

Reference yield:

1,4-bromoiodobenzene (589-87-7) + 3,4-difluoro-N-methoxy-N-methylbenzamide (188345-25-7) → (4-bromophenyl)-(3,4-difluorophenyl)-methanone (844878-99-5)

Guidance literature:

1,4-bromoiodobenzene; With TurboGrignard; In tetrahydrofuran; at -20 ℃; for 3h; Schlenk technique; Inert atmosphere;

3,4-difluoro-N-methoxy-N-methylbenzamide; In tetrahydrofuran; toluene; at 23 ℃; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1039/d0ob00813c

upstream raw materials:

(4-bromophenyl)-(3,4-difluorophenyl)-methanol

1-bromo-3,4-difluorobenzene

4-bromo-benzaldehyde

1,4-bromoiodobenzene

Downstream raw materials:

(3,4-difluorophenyl)-(4'-hydroxy-3'-methylbiphenyl-4-yl)-methanone

(3,4-difluorophenyl)-(4'-methoxy-3'-methylbiphenyl-4-yl)-methanone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 844878-99-5 4-BROMO-3',4'-DIFLUOROBENZOPHENONE

Send

Send

Metric Ton KG G Pound L ML

Send

Send