Chemical Property of 1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
Chemical Property:
- PSA：128.77000
- LogP:5.14190
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble2mg/mL, clear (warmed)
- Purity/Quality:
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99%, *data from raw suppliers
Bioymifi(~90%) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22
- MSDS Files:
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Useful:
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Description
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TNF-related apoptosis-inducing ligand (TRAIL or Apo2L), a member of this family, activates apoptosis in a variety of tumor cell lines by signaling through the death receptors, DR4 and DR5. Bioymifi directly activates DR5 (Kd = 1.2 μM; IC50 = 2 μM), inducing DR5 clustering, which leads to the initiation of FADD/caspase-8-dependent apoptosis in various cancer cells.
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Uses
Bioymifi is thiazolidinone derivative that induces apoptosis. It is TRAIL receptor DR5 binding agent useful in human cancer cells.
