(±)11(12)-EET

Base Information

Chemical Name:(±)11(12)-EET
CAS No.:123931-40-8
Molecular Formula:C20H32O3
Molecular Weight:320.47
Hs Code.:
Mol file:123931-40-8.mol

Synonyms:(5Z,8Z)-10-{(2S,3R)-3-[(2Z)-2-Octen-1-yl]-2-oxiranyl}-5,8-decadie noic acid;

Suppliers and Price of (±)11(12)-EET

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid ~100?μg/mLinethanol,≥95%
25 μg
$ 238.00

Sigma-Aldrich
11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid ~100μg/mL in ethanol, ≥95%
25ug
$ 230.00

Cayman Chemical
(±)11(12)-EET ≥95%
500μg
$ 360.00

Cayman Chemical
(±)11(12)-EET ≥95%
100μg
$ 115.00

Cayman Chemical
(±)11(12)-EET ≥95%
50μg
$ 65.00

Cayman Chemical
(±)11(12)-EET ≥95%
25μg
$ 36.00

Total 7 raw suppliers

Chemical Property of (±)11(12)-EET

Chemical Property:

Boiling Point:461.8±33.0 °C(Predicted)
PKA:4.75±0.10(Predicted)
Flash Point:9℃
PSA：49.83000
Density:0.983±0.06 g/cm3(Predicted)
LogP:5.42790
Storage Temp.:?20°C

Purity/Quality:

≥95% ^*data from raw suppliers

11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid ~100?μg/mLinethanol,≥95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:F
Statements: 11
Safety Statements: 7-16

MSDS Files:

Useful:

Description (±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET has been shown, along with 8(9)-EET , to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells. It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM. 11(12)-EET (50 μg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation. It also has anti-inflammatory, angiogenic, and cardioprotective properties.

Technology Process of (±)11(12)-EET

There total 6 articles about (±)11(12)-EET which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 506-32-1,236743-58-1
all cis 5,8,11,14-eicosatetraenoic acid

: 123931-40-8,81276-02-0,87173-81-7
11(S),12(R)-Epoxyeicosatrienoic acid

: 123931-38-4,81276-02-0,87173-81-7
11(R),12(S)-Epoxyeicosatrienoic acid

: 129172-62-9,81246-85-7
8(R),9(S)-epoxy-(5Z,11Z,14Z)-eicosatrienoic acid

: 105304-92-5,81276-03-1
14(S),15(R)-Epoxyeicosatrienoic acid

: 98103-48-1,81276-03-1
14(R),15(S)-Epoxyeicosatrienoic acid

Guidance literature:: With nicotinamide adenine dinucleotide phosphate; In ethanol; at 37 ℃; for 0.5h; pH=7.4; optical yield given as %ee; enantioselective reaction; Tris-buffer; Enzymatic reaction;
DOI:10.1002/rcm.4760