Oxazolo(5,4-b)pyridin-2(1H)-one, 1-(3-(4-(4-fluorophenyl)-1-piperazinyl)propyl)-

Base Information

• Chemical Name: Oxazolo(5,4-b)pyridin-2(1H)-one, 1-(3-(4-(4-fluorophenyl)-1-piperazinyl)propyl)-
• CAS No.: 162254-18-4
• Molecular Formula: C₁₉H₂₁FN₄O₂
• Molecular Weight: 356.4
• DSSTox Substance ID: DTXSID80167342
• Nikkaji Number: J653.323J
• Wikidata: Q83036694
• ChEMBL ID: CHEMBL25898
• Mol file: 162254-18-4.mol

Synonyms:1-(3-(4-(4-Fluorophenyl)-1-piperazinyl)propyl)oxazolo(5,4-b)pyridin-2(1H)-one;Oxazolo(5,4-b)pyridin-2(1H)-one, 1-(3-(4-(4-fluorophenyl)-1-piperazinyl)propyl)-;162254-18-4;1-[3-[4-(4-Fluorophenyl)-1-piperazinyl]propyl]oxazolo[5,4-b]pyridin-2(1H)-one;CHEMBL25898;DTXSID80167342;LS-100908

Chemical Property of Oxazolo(5,4-b)pyridin-2(1H)-one, 1-(3-(4-(4-fluorophenyl)-1-piperazinyl)propyl)-

Chemical Property:

• Vapor Pressure: 1.41E-11mmHg at 25°C
• Boiling Point: 536.4°Cat760mmHg
• Flash Point: 278.2°C
• Density: 1.284g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 356.16485409
• Heavy Atom Count: 26
• Complexity: 478

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCCN2C3=C(N=CC=C3)OC2=O)C4=CC=C(C=C4)F

Technology Process of Oxazolo(5,4-b)pyridin-2(1H)-one, 1-(3-(4-(4-fluorophenyl)-1-piperazinyl)propyl)-

There total 1 articles about Oxazolo(5,4-b)pyridin-2(1H)-one, 1-(3-(4-(4-fluorophenyl)-1-piperazinyl)propyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(3-bromopropyl)oxazolo<5,4-b>pyridin-2(1H)-one (142714-73-6) + 1-(4-Fluorophenyl)piperazine (2252-63-3) → 1-<3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>oxazolo<5,4-b>pyridin-2(1H)-one (162254-18-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 85 ℃; for 12h;

DOI:10.1021/jm00008a006

upstream raw materials:

1-(3-bromopropyl)oxazolo<5,4-b>pyridin-2(1H)-one

1-(4-Fluorophenyl)piperazine