1-BOC-4-(3-FLUOROPHENYL)-PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-(3-FLUOROPHENYL)-PIPERIDINE
• CAS No.: 1086398-00-6
• Molecular Formula: C16H22FNO2
• Molecular Weight: 279.355
• Hs Code.: 2933399090
• Mol file: 1086398-00-6.mol

Synonyms:1-BOC-4-(3-FLUOROPHENYL)-PIPERIDINE;tert-Butyl 4-(3-fluorophenyl)piperidine-1-carboxylate

Chemical Property of 1-BOC-4-(3-FLUOROPHENYL)-PIPERIDINE

Chemical Property:

• PSA: 29.54000
• LogP: 3.87810

Purity/Quality:

95-99% ^*data from raw suppliers

1-Boc-4-(3-fluorophenyl)-piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-(3-FLUOROPHENYL)-PIPERIDINE

There total 8 articles about 1-BOC-4-(3-FLUOROPHENYL)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ tert-butyl 4-(3-fluorophenyl)piperidine-1-carboxylate (1086398-00-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 45 ℃; for 2h;

Reference yield: 7.0%

tert-butyl 4-(2-chloro-5-fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylate → tert-butyl 4-(3-fluorophenyl)piperidine-1-carboxylate (1086398-00-6) + tert-butyl 4-(2-chloro-5-fluoro-phenyl)piperidine-1-carboxylate

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 15 ℃; for 40h; under 775.743 Torr; Inert atmosphere;

Reference yield:

4-(3-fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (358722-19-7) → tert-butyl 4-(3-fluorophenyl)piperidine-1-carboxylate (1086398-00-6)

Guidance literature:

hydrogenation;

DOI:10.1016/j.bmcl.2007.12.029

upstream raw materials:

4-(3-fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

3-fluorobromobenzene

tert-butyl 4-iodopiperidine-1-carboxylate

4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

4-(3-fluorophenyl)piperidine

Refernces

• 1、 Yang, Shaoning,Lu, Dingqiang,Ouyang, Pingkai. "Design, synthesis and evaluation of substituted piperidine based KCNQ openers as novel antiepileptic agents". supporting information. p. 1731 - 1735. Retrieved 2018/05/04.
• 2、 Tang, Haifeng,Yan, Yan,Feng, Zhe,De Jesus, Reynalda K.,Yang, Lihu,Levorse, Dorothy A.,Owens, Karen A.,Akiyama, Taro E.,Bergeron, Raynald,Castriota, Gino A.,Doebber, Thomas W.,Ellsworth, Kenneth P.,Lassman, Michael E.,Li, Cai,Wu, Margaret S.,Zhang, Bei B.,Chapman, Kevin T.,Mills, Sander G.,Berger, Joel P.,Pasternak, Alexander. "Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities". scheme or table. p. 6088 - 6092. Retrieved 2010/11/18.