1H-Indole-1-carboxylic acid, 2,3-dihydro-2-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-, 1,1-diMethylethyl ester, (2S)-

Base Information

Chemical Name:1H-Indole-1-carboxylic acid, 2,3-dihydro-2-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-, 1,1-diMethylethyl ester, (2S)-
CAS No.:197460-26-7
Molecular Formula:C21H25NO5S
Molecular Weight:403.499
Hs Code.:
Mol file:197460-26-7.mol

Synonyms:1H-Indole-1-carboxylic acid, 2,3-dihydro-2-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-, 1,1-diMethylethyl ester, (2S)-

Suppliers and Price of 1H-Indole-1-carboxylic acid, 2,3-dihydro-2-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-, 1,1-diMethylethyl ester, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of 1H-Indole-1-carboxylic acid, 2,3-dihydro-2-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-, 1,1-diMethylethyl ester, (2S)-

Chemical Property:

PSA：81.29000
LogP:5.21250

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
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Technology Process of 1H-Indole-1-carboxylic acid, 2,3-dihydro-2-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-, 1,1-diMethylethyl ester, (2S)-

There total 4 articles about 1H-Indole-1-carboxylic acid, 2,3-dihydro-2-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-, 1,1-diMethylethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 98-59-9
p-toluenesulfonyl chloride

: 197460-25-6
(S)-tert-butyl 2-(hydroxymethyl)indoline-1-carboxylate

: 197460-26-7
(S)-tert-butyl 2-((tosyloxy)methyl)indoline-1-carboxylate

Guidance literature:: In pyridine; dichloromethane; at 0 ℃; for 18h;
DOI:10.1021/jo9708856

Reference yield:

: 79815-20-6,78348-24-0
(S)-indoline-2-carboxylic acid

: 197460-26-7
(S)-tert-butyl 2-((tosyloxy)methyl)indoline-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / BH₃*THF / 24 h / 0 °C

2: 94 percent / CH₂Cl₂ / 16 h / 0 °C

3: 85 percent / pyridine; CH₂Cl₂ / 18 h / 0 °C

With borane-THF; In pyridine; dichloromethane;
DOI:10.1021/jo9708856

Reference yield:

: 27640-33-1
(2S)-2,3-dihydro-1H-indole-2-ylmethanol

: 197460-26-7
(S)-tert-butyl 2-((tosyloxy)methyl)indoline-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / CH₂Cl₂ / 16 h / 0 °C

2: 85 percent / pyridine; CH₂Cl₂ / 18 h / 0 °C

In pyridine; dichloromethane;
DOI:10.1021/jo9708856