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Technology Process of HPI-4,Hedgehog Pathway Inhibitor 4

HPI-4,Hedgehog Pathway Inhibitor 4

Base Information
  • Chemical Name:HPI-4,Hedgehog Pathway Inhibitor 4
  • CAS No.:302803-72-1
  • Molecular Formula:C17H9Cl2N3O2
  • Molecular Weight:358.17826
  • Hs Code.:
  • Mol file:302803-72-1.mol
HPI-4,Hedgehog Pathway Inhibitor 4

Synonyms:HPI-4,Hedgehog Pathway Inhibitor 4;Ciliobrevin A;2,4-Dichloro-a-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-benzenepropanenitrile;Hedgehog Pathway Inhibitor 4

Suppliers and Price of HPI-4,Hedgehog Pathway Inhibitor 4
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Ciliobrevin A
  • 10mg
  • $ 446.00
  • Usbiological
  • Ciliobrevin A
  • 10mg
  • $ 446.00
  • TRC
  • CiliobrevinA
  • 10mg
  • $ 155.00
  • Tocris
  • CiliobrevinA ≥98%(HPLC)
  • 25
  • $ 386.00
  • Tocris
  • CiliobrevinA ≥98%(HPLC)
  • 5
  • $ 102.00
  • Sigma-Aldrich
  • HPI-4 ≥98% (HPLC)
  • 5mg
  • $ 113.00
  • Sigma-Aldrich
  • HPI-4 ≥98% (HPLC)
  • 25mg
  • $ 451.00
  • DC Chemicals
  • CiliobrevinA(HPI4) >98%
  • 100 mg
  • $ 500.00
  • DC Chemicals
  • CiliobrevinA(HPI4) >98%
  • 1 g
  • $ 1800.00
  • DC Chemicals
  • CiliobrevinA(HPI4) >98%
  • 250 mg
  • $ 850.00
Total 20 raw suppliers
Chemical Property of HPI-4,Hedgehog Pathway Inhibitor 4
Chemical Property:
  • Boiling Point:564.5±50.0 °C(Predicted) 
  • PKA:6.46±0.20(Predicted) 
  • PSA：89.51000 
  • Density:1.471±0.06 g/cm3(Predicted) 
  • LogP:3.00128 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: soluble10mg/mL, clear 
Purity/Quality:

99%, *data from raw suppliers

Ciliobrevin A *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes:Xn,N 
  • Statements: 22-50/53 
  • Safety Statements: 60-61 
MSDS Files:

SDS file from LookChem

Useful:
  • Description Ciliobrevin A is a hedgehog pathway inhibitor that blocks sonic hedgehog (Shh)-induced hedgehog pathway activation (IC50 = 7 μM). It disrupts primary cilia formation and inhibits the dynein-dependent microtubial gliding and ATPase activities of the cytoplasmic ATPases associated with various cellular activities (AAA+) family. Ciliobrevin A also inhibits mammalian target of rapamycin complex 1 (mTORC1) activity in uninfected and human cytomegalovirus (HCMV)-infected cells, suggesting that mTORC1 activation requires dynein-dependent transport for cellular activation.
  • Uses Ciliobrevin A is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics. Ciliobrevin A inhibited proliferation of cerebellar granula neuron precursor cells, an important model of HH signaling. Hedgehog pathway inhibitor (HP1-4) has been used for the inhibition of dynein ATPase in Leishmania.
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