4,6-Dibromoisophthalic acid

Base Information

• Chemical Name: 4,6-Dibromoisophthalic acid
• CAS No.: 24063-27-2
• Molecular Formula: C8H4Br2O4
• Molecular Weight: 323.925
• Mol file: 24063-27-2.mol

Synonyms:4,6-Dibromoisophthalic acid

Chemical Property of 4,6-Dibromoisophthalic acid

Chemical Property:

• Melting Point: 250-254 °C
• Boiling Point: 444.9±45.0 °C(Predicted)
• PKA: 1.95±0.10(Predicted)
• PSA: 74.60000
• Density: 2.205±0.06 g/cm3(Predicted)
• LogP: 2.60800

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-Dibromoisophthalic acid

There total 7 articles about 4,6-Dibromoisophthalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1,5-dibromo-2,4-dimethylbenzene (615-87-2) → 4,6-dibromobenzene-1,3-dicarboxylic acid (24063-27-2)

Guidance literature:

1,5-dibromo-2,4-dimethylbenzene; With pyridine; potassium hydroxide; In water; at 70 ℃;

With potassium permanganate; In water; for 12h;

DOI:10.1002/chem.202000661

Reference yield:

2,4-dibromo-5-methyl-benzoic acid (100960-64-3) → 4,6-dibromobenzene-1,3-dicarboxylic acid (24063-27-2)

Guidance literature:

With permanganate(VII) ion;

Reference yield:

m-xylene (108-38-3,104809-90-7) → 4,6-dibromobenzene-1,3-dicarboxylic acid (24063-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; bromine / 32 h / 0 - 20 °C / Darkness

2: potassium permanganate / tert-butyl alcohol; water / 2 h / Reflux

With potassium permanganate; bromine; iodine; In water; tert-butyl alcohol;

DOI:10.1002/chem.201203108

upstream raw materials:

2,4-dibromo-5-methyl-benzoic acid

1,5-dibromo-2,4-dimethylbenzene

m-xylene

Downstream raw materials:

dimethyl 4,6-dibromobenzene-1,3-dioate

4,6-dinitro-isophthalic acid dimethyl ester

4,6-dibromobenzene-1,3-dicarboxylic acid dichloride

4,6-dianilino-isophthalic acid

Refernces

• 1、 Hein, Robert,Borissov, Arseni,Smith, Martin D.,Beer, Paul D.,Davis, Jason J.. "A halogen-bonding foldamer molecular film for selective reagentless anion sensing in water". . p. 4849 - 4852. Retrieved 2019.
• 2、 Malytskyi, Volodymyr,da Silva, Vinicius Demetrio,Siri, Olivier,Giorgi, Michel,Raimundo, Jean-Manuel. "Versatile synthesis of tunable N,S-bridged-[1.1.1.1]-cyclophanes promoted by ester functions". . p. 6363 - 6367. Retrieved 2016.
• 3、 Zhen, Cian-Jhe,Lu, Shu-Feng,Lin, Min-Hwa,Wu, Jay-Tai,Chao, Ito,Lin, Chih-Hsiu. "Singlet Biradical Versus Triplet Biradical/Zwitterion Characteristics in Isomers of C6?C5?C6?C7?C6-Fused Pentacyclic Aromatic Hydrocarbons Revealed through Reactivity Patterns". supporting information. p. 16682 - 16689. Retrieved 2021/11/01.
• 4、 Audibert, Edwige,Gianga, Tiberiu-M.,Kociok-K?hn, Gabriele,Panto?, G. Dan,Trandafir, Anamaria. "Discovery of an all-donor aromatic [2]catenane". . p. 9685 - 9690. Retrieved 2020/10/14.