4'-Trifluoromethoxy-biphenyl-4-carboxylic acid

Base Information

Chemical Name:4'-Trifluoromethoxy-biphenyl-4-carboxylic acid
CAS No.:728919-11-7
Molecular Formula:C14H9F3O3
Molecular Weight:282.219
Hs Code.:2918990090
European Community (EC) Number:673-784-0
DSSTox Substance ID:DTXSID00375321
Wikidata:Q82163852
Mol file:728919-11-7.mol

Synonyms:728919-11-7;4'-Trifluoromethoxy-biphenyl-4-carboxylic acid;4-(4-Trifluoromethoxyphenyl)benzoic acid;4-[4-(trifluoromethoxy)phenyl]benzoic Acid;4'-trifluoromethoxybiphenyl-4-carboxylic acid;SCHEMBL505538;DTXSID00375321;MFCD04117415;AKOS010253754;NCGC00374163-01;BS-29299;CS-0205130;4'-Trifluoromethoxy-biphenyl-4-carboxylicacid;4-[4-(trifluoromethyloxy)phenyl]benzoic acid;4'-(trifluoromethoxy)biphenyl-4-carboxylic acid;A837660

Suppliers and Price of 4'-Trifluoromethoxy-biphenyl-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4'-Trifluoromethoxy-biphenyl-4-carboxylicacid 95+%
5g
$ 713.00

Crysdot
4'-Trifluoromethoxy-biphenyl-4-carboxylicacid 95+%
1g
$ 198.00

American Custom Chemicals Corporation
4'-TRIFLUOROMETHOXY-BIPHENYL-4-CARBOXYLIC ACID 95.00%
1G
$ 1280.66

AHH
4-Trifluoromethoxybiphenyl-4-carboxylicacid 98%
1g
$ 280.00

Total 9 raw suppliers

Chemical Property of 4'-Trifluoromethoxy-biphenyl-4-carboxylic acid

Chemical Property:

Melting Point:258-259.9°C
Boiling Point:366.3oC at 760 mmHg
Flash Point:175.3oC
PSA：46.53000
Density:1.359g/cm3
LogP:3.95040
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:282.05037863
Heavy Atom Count:20
Complexity:327

Purity/Quality:

97% ^*data from raw suppliers

4'-Trifluoromethoxy-biphenyl-4-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC=C(C=C2)OC(F)(F)F)C(=O)O

Technology Process of 4'-Trifluoromethoxy-biphenyl-4-carboxylic acid

There total 2 articles about 4'-Trifluoromethoxy-biphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 398156-35-9
4'-(trifluoromethoxy)-[1,1′-biphenyl]-4-carbaldehyde

: 728919-11-7
4-(4-(trifluoromethoxy)phenyl)benzoic acid

Guidance literature:: With Jones reagent; In acetone; at 0 ℃;

Reference yield:

: 586-76-5
4-Bromobenzoic acid

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 728919-11-7
4-(4-(trifluoromethoxy)phenyl)benzoic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2016.11.051

Reference yield: 79.0%

: 728919-11-7
4-(4-(trifluoromethoxy)phenyl)benzoic acid

: 4-(aminomethyl)-1-methyl-5,6,7,8-tetrahydroisoquinolin-3(2H)-one

: N-((1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolin-4-yl)methyl)-4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-carboxamide

Guidance literature:: 4-(4-(trifluoromethoxy)phenyl)benzoic acid; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

4-(aminomethyl)-1-methyl-5,6,7,8-tetrahydroisoquinolin-3(2H)-one; In dichloromethane; at 20 ℃; for 7h;
DOI:10.1039/d0ra09250a