N-BOC-5-CHLOROTRYPTOPHOL

Base Information

• Chemical Name: N-BOC-5-CHLOROTRYPTOPHOL
• CAS No.: 898746-66-2
• Molecular Formula: C₁₅H₁₈ClNO₃
• Molecular Weight: 295.766
• Mol file: 898746-66-2.mol

Synonyms:N-BOC-5-CHLOROTRYPTOPHOL

Chemical Property of N-BOC-5-CHLOROTRYPTOPHOL

Chemical Property:

• PSA: 51.46000
• LogP: 3.61270

Purity/Quality:

97% ^*data from raw suppliers

N-BOC-5-CHLOROTRYPTOPHOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-5-CHLOROTRYPTOPHOL

There total 3 articles about N-BOC-5-CHLOROTRYPTOPHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C21H32ClNO3Si → tert-butyl 5-chloro-3-(2-hydroxyethyl)-1H-indole-1-carboxylate (898746-66-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 5h;

DOI:10.1055/a-1310-5213

Reference yield:

C16H24ClNOSi → tert-butyl 5-chloro-3-(2-hydroxyethyl)-1H-indole-1-carboxylate (898746-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / dichloromethane / 2 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 0 - 20 °C

With dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;

DOI:10.1055/a-1310-5213

Reference yield:

2-(5-chloro-1H-indol-3-yl)ethanol (61220-51-7) → tert-butyl 5-chloro-3-(2-hydroxyethyl)-1H-indole-1-carboxylate (898746-66-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 4.5 h / 0 - 20 °C

2: dmap / dichloromethane / 2 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 0 - 20 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1055/a-1310-5213

upstream raw materials:

2-(5-chloro-1H-indol-3-yl)ethanol