Methyl 6-(hydroxyMethyl)-4-Methylpicolinate

Base Information

• Chemical Name: Methyl 6-(hydroxyMethyl)-4-Methylpicolinate
• CAS No.: 69971-39-7
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.18854
• Hs Code.: 2933399090
• Mol file: 69971-39-7.mol

Synonyms:Methyl 6-(hydroxyMethyl)-4-Methylpicolinate

Chemical Property of Methyl 6-(hydroxyMethyl)-4-Methylpicolinate

Chemical Property:

• Boiling Point: 349.6±42.0 °C(Predicted)
• PKA: 13.05±0.10(Predicted)
• PSA: 59.42000
• Density: 1.202±0.06 g/cm3(Predicted)
• LogP: 0.66890
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl6-(hydroxymethyl)-4-methylpicolinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-(hydroxyMethyl)-4-Methylpicolinate

There total 3 articles about Methyl 6-(hydroxyMethyl)-4-Methylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

dimethyl 4-methylpyridine-2,6-dicarboxylate (4566-82-9) → methyl 6-(hydroxymethyl)-4-methylpicolinate (69971-39-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane; at 0 - 20 ℃;

DOI:10.1002/anie.201814751

Reference yield: 67.0%

→ methyl 6-(hydroxymethyl)-4-methylpicolinate (69971-39-7)

Guidance literature:

With methanol; sodium tetrahydroborate; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

2,6-dichloro-4-picoline (39621-00-6) → methyl 6-(hydroxymethyl)-4-methylpicolinate (69971-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / N,N-dimethyl-formamide / 16 h / 80 °C / 2585.81 Torr

2: sodium hydroxide; methanol / dichloromethane / 12 h / 0 °C

With methanol; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

dimethyl 4-methylpyridine-2,6-dicarboxylate

2,6-dichloro-4-picoline