tert-butyl 3,3-dimethyl-5-oxopiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3,3-dimethyl-5-oxopiperidine-1-carboxylate
• CAS No.: 1000894-83-6
• Molecular Formula: C₁₂H₂₁NO₃
• Molecular Weight: 227.304
• Mol file: 1000894-83-6.mol

Synonyms:tert-butyl 3,3-dimethyl-5-oxopiperidine-1-carboxylate

Chemical Property of tert-butyl 3,3-dimethyl-5-oxopiperidine-1-carboxylate

Chemical Property:

• PSA: 46.61000
• LogP: 2.16040

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,3-Dimethyl-5-oxo-1-piperidinecarboxylicAcid1,1-DimethylethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3,3-Dimethyl-5-oxo-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester is reactant in the synthesis of novel inhibitors of HDM2-p53 protein-protein interactions.

Technology Process of tert-butyl 3,3-dimethyl-5-oxopiperidine-1-carboxylate

There total 7 articles about tert-butyl 3,3-dimethyl-5-oxopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H23NO3 (1189570-45-3) → C12H21NO3 (1000894-83-6)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃;

Reference yield:

C14H21NO → C12H21NO3 (1000894-83-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; 10 wt% Pd(OH)2 on carbon

2: sodium hydroxide / tetrahydrofuran

3: Dess-Martin periodane

With 10 wt% Pd(OH)2 on carbon; hydrogen; Dess-Martin periodane; sodium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2014.02.055

Reference yield:

5,5-dimethyl-piperidin-3-ol → C12H21NO3 (1000894-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran

2: Dess-Martin periodane

With Dess-Martin periodane; sodium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2014.02.055

upstream raw materials:

C₁₂H₂₃NO₃

(3R,7aS)-3-Phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

Downstream raw materials:

C₃₃H₄₄F₃N₃O₆

C₂₀H₂₆F₃NO₅

Refernces

• 1、 -. "Substituted Piperidines that Increase P53 Activity and the Uses Thereof". Page/Page column 90. . Retrieved 2008/06/13.