4-Iodo-6-methoxynicotinaldehyde

Base Information

Chemical Name:4-Iodo-6-methoxynicotinaldehyde
CAS No.:893566-85-3
Molecular Formula:C₇H₆INO₂
Molecular Weight:263.035
Hs Code.:
DSSTox Substance ID:DTXSID301269145

Synonyms:4-iodo-6-methoxynicotinaldehyde;893566-85-3;MFCD18259571;4-iodo-6-methoxypyridine-3-carbaldehyde;SCHEMBL587088;WTVMDONQQKRTID-UHFFFAOYSA-N;DTXSID301269145;AS-38400;SY258318;4-Iodo-6-methoxy-3-pyridinecarboxaldehyde

Suppliers and Price of 4-Iodo-6-methoxynicotinaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 4-Iodo-6-methoxynicotinaldehyde

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:262.94433
Heavy Atom Count:11
Complexity:142

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=NC=C(C(=C1)I)C=O

Technology Process of 4-Iodo-6-methoxynicotinaldehyde

There total 5 articles about 4-Iodo-6-methoxynicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 65873-72-5
6-methoxy-3-pyridinecarboxaldehyde

: 893566-85-3
4-iodo-6-methoxypyridine-3-carbaldehyde

Guidance literature:: 6-methoxy-3-pyridinecarboxaldehyde; With n-butyllithium; N,N',N'-trimethylenediamine; In tetrahydrofuran; hexanes; at -70 - -45 ℃; for 4.5h;

With iodine; In tetrahydrofuran; hexanes; at -70 - 20 ℃; for 3.5h;

Reference yield:

: 5-(bromomethyl)-4-iodo-2-methoxypyridine

: 893566-85-3
4-iodo-6-methoxypyridine-3-carbaldehyde

Guidance literature:: With 4-methylmorpholine N-oxide; In acetonitrile; at 0 - 20 ℃; for 2.5h; Molecular sieve;

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 893566-85-3
4-iodo-6-methoxypyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 1 h / -78 °C

2.1: n-butyllithium; N,N',N'-trimethylenediamine / tetrahydrofuran / 1.5 h / -78 °C

2.2: 16 h / 20 °C

With n-butyllithium; N,N',N'-trimethylenediamine; In tetrahydrofuran;