Dioxopromethazine

Base Information

Chemical Name:Dioxopromethazine
CAS No.:13754-56-8
Molecular Formula:C₁₇H₂₀N₂O₂S*ClH
Molecular Weight:352.885
Hs Code.:
UNII:6OOT1MR6XS
DSSTox Substance ID:DTXSID80929821
Nikkaji Number:J14.784B
Wikidata:Q27265239
ChEMBL ID:CHEMBL3580712
Mol file:13754-56-8.mol

Synonyms:dioxopromethazine;dioxopromethazine monohydrochloride;Prothanon

Suppliers and Price of Dioxopromethazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PromethazineSulfone
25mg
$ 945.00

Medical Isotopes, Inc.
PromethazineSulfone
100 mg
$ 2400.00

Medical Isotopes, Inc.
PromethazineSulfone
2.5 mg
$ 675.00

Chemcia Scientific
[2-(5,5-Dioxo-5H-5lambda*6*-phenothiazin-10-yl)-1-methyl-ethyl]-dimethyl-aminehydrochloride 95%
100 G
$ 250.00

American Custom Chemicals Corporation
1-(5,5-DIOXOPHENOTHIAZIN-10-YL)-N,N-DIMETHYLPROPAN-2-AMINE 95.00%
10G
$ 1334.03

American Custom Chemicals Corporation
1-(5,5-DIOXOPHENOTHIAZIN-10-YL)-N,N-DIMETHYLPROPAN-2-AMINE 95.00%
5G
$ 909.56

Total 76 raw suppliers

Chemical Property of Dioxopromethazine

Chemical Property:

Appearance/Colour:white powder
Vapor Pressure:2.57E-09mmHg at 25°C
Melting Point:127-129 °C
Refractive Index:1.605
Boiling Point:478.451 °C at 760 mmHg
PKA:8.88±0.50(Predicted)
Flash Point:243.159 °C
PSA：49.00000
Density:1.224 g/cm³
LogP:4.06680
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly, Heated)
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:316.12454906
Heavy Atom Count:22
Complexity:455

Purity/Quality:

99% ^*data from raw suppliers

PromethazineSulfone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CN1C2=CC=CC=C2S(=O)(=O)C3=CC=CC=C31)N(C)C
Uses Promethazine Sulfone, is a metabolite of Promethazine (P757000), which is a drug from antihistamine family. It has strong sedative effects and in some countries used for the treatment of insomnia. It has also antiemetic and anticholinergic properties.

Technology Process of Dioxopromethazine

There total 4 articles about Dioxopromethazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

: 13582-96-2,13582-97-3,13754-56-8
9,9-Dioxopromethazin

: 13582-95-1,13582-98-4,13754-57-9,15374-15-9,17591-91-2,29432-24-4,13754-56-8
dioxopromethazine hydrochloride

Guidance literature:: With hydrogenchloride; In acetone; at 20 ℃; for 0.1h; pH=4;

Reference yield: 90.2%

: 60-87-7
10-[2-(dimethylamino)propyl]phenothiazine

: 13582-96-2,13582-97-3,13754-56-8
9,9-Dioxopromethazin

Guidance literature:: With oxygen; palladium diacetate; sodium carbonate; triphenylphosphine; In toluene; at 80 ℃; for 18h; Reagent/catalyst; Temperature; Green chemistry;