1-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinolin-1-yl)ethyl]pyrrolidin-2-one

Base Information

• Chemical Name: 1-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinolin-1-yl)ethyl]pyrrolidin-2-one
• CAS No.: 47216-65-9
• Molecular Formula: C₁₇H₂₄N₂O₃
• Molecular Weight: 304.389
• Mol file: 47216-65-9.mol

Synonyms:1-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinolin-1-yl)ethyl]pyrrolidin-2-one

Chemical Property of 1-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinolin-1-yl)ethyl]pyrrolidin-2-one

Chemical Property:

• PSA: 50.80000
• LogP: 2.16980

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinolin-1-yl)ethyl]pyrrolidin-2-one

There total 6 articles about 1-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinolin-1-yl)ethyl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1-(3,3-dimethoxypropyl)-2-pyrrolidone (73186-31-9) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 6,7-dimethoxy-1-<2-(2-oxo-1-pyrrolidinyl)ethyl>-1,2,3,4-tetrahydroisoquinoline (47216-65-9)

Guidance literature:

In hydrogenchloride; for 2h; Heating; pH 1-2;

DOI:10.1248/cpb.28.3632

Reference yield:

β-(pyrrolidine-2) ethyl-1 dimethoxy-6,7 dihydro-3,4 isoquinoline (70241-07-5) → 6,7-dimethoxy-1-<2-(2-oxo-1-pyrrolidinyl)ethyl>-1,2,3,4-tetrahydroisoquinoline (47216-65-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; chloroform; water; for 20h; Yield given; Ambient temperature;

DOI:10.1248/cpb.28.3632

Reference yield:

3-(2-oxopyrrolidin-1-yl)propanenitrile (7663-76-5) → 6,7-dimethoxy-1-<2-(2-oxo-1-pyrrolidinyl)ethyl>-1,2,3,4-tetrahydroisoquinoline (47216-65-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / p-toluene sulfonic acid monohydrate / 20 h / Heating

2: 80 percent / 5 h / 170 - 180 °C

3: polyphosphate ester / CHCl₃ / reflux, 4.5 h then R_.T_., 8 h

4: NaBH₄ / CHCl₃; H₂O; methanol / 20 h / Ambient temperature

With sodium tetrahydroborate; polyphosphate ester; toluene-4-sulfonic acid; In methanol; chloroform; water;

DOI:10.1248/cpb.28.3632

upstream raw materials:

β-(pyrrolidine-2) ethyl-1 dimethoxy-6,7 dihydro-3,4 isoquinoline

1-(3,3-dimethoxypropyl)-2-pyrrolidone

2-(3,4-dimethoxyphenyl)-ethylamine

3-(2-oxopyrrolidin-1-yl)propanenitrile