Chemical Property of Sacubitrilat
Chemical Property:
- Boiling Point:705.4±60.0 °C(Predicted)
- PKA:4.59±0.23(Predicted)
- PSA：107.19000
- Density:1 +-.0.06 g/cm3(Predicted)
- LogP:4.19680
- Storage Temp.:Sealed in dry,Room Temperature
- XLogP3:3
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:10
- Exact Mass:383.17327290
- Heavy Atom Count:28
- Complexity:521
- Purity/Quality:
-
99%, *data from raw suppliers
DesethylSacubitril *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC(CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O)C(=O)O
- Isomeric SMILES:C[C@H](C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O)C(=O)O
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Uses
Desethyl Sacubitril is an impurity in the synthesis of Sacubitril (S080895), an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
