4(3H)-Quinazolinone, 3-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]-2-[4-(dimethylamino)phenyl]-8-methoxy-

Base Information

• Chemical Name: 4(3H)-Quinazolinone, 3-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]-2-[4-(dimethylamino)phenyl]-8-methoxy-
• CAS No.: 446293-88-5
• Molecular Formula: C₃₀H₃₄N₄O₄
• Molecular Weight: 514.624
• Mol file: 446293-88-5.mol

Synonyms:4(3H)-Quinazolinone, 3-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]-2-[4-(dimethylamino)phenyl]-8-methoxy-

Chemical Property of 4(3H)-Quinazolinone, 3-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]-2-[4-(dimethylamino)phenyl]-8-methoxy-

Chemical Property:

• PSA: 69.06000
• LogP: 4.15150

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4(3H)-Quinazolinone, 3-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]-2-[4-(dimethylamino)phenyl]-8-methoxy-

There total 5 articles about 4(3H)-Quinazolinone, 3-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]-2-[4-(dimethylamino)phenyl]-8-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-methoxybenzoic acid (3177-80-8) → 3-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-2-(4-dimethylamino-phenyl)-8-methoxy-3H-quinazolin-4-one (446293-88-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 0 °C

2: pTSA / toluene / Heating

With pyridine; toluene-4-sulfonic acid; In dichloromethane; toluene;

DOI:10.1016/S0960-894X(01)00804-6

Reference yield:

4-(dimethylamino)benzoyl chloride (4755-50-4) → 3-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-2-(4-dimethylamino-phenyl)-8-methoxy-3H-quinazolin-4-one (446293-88-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 0 °C

2: pTSA / toluene / Heating

With pyridine; toluene-4-sulfonic acid; In dichloromethane; toluene;

DOI:10.1016/S0960-894X(01)00804-6

Reference yield:

N-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-2-(4-dimethylamino-benzoylamino)-3-methoxy-benzamide → 3-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-2-(4-dimethylamino-phenyl)-8-methoxy-3H-quinazolin-4-one (446293-88-5)

Guidance literature:

With sulfuric acid; acetic acid; at 100 ℃; for 0.25h;

DOI:10.1016/S0960-894X(01)00804-6

upstream raw materials:

2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-amine

4-(dimethylamino)benzoyl chloride

2-amino-3-methoxybenzoic acid

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