2-Methyl-6-trifluoroMethyl-1H-indole

Base Information

• Chemical Name: 2-Methyl-6-trifluoroMethyl-1H-indole
• CAS No.: 57330-48-0
• Molecular Formula: C₁₀H₈F₃N
• Molecular Weight: 199.175
• Mol file: 57330-48-0.mol

Synonyms:2-Methyl-6-trifluoroMethyl-1H-indole;2-Methyl-6-trifluoroMethyl indole

Chemical Property of 2-Methyl-6-trifluoroMethyl-1H-indole

Chemical Property:

• PSA: 15.79000
• LogP: 3.49510
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-6-(trifluoromethyl)-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-6-trifluoroMethyl-1H-indole

There total 7 articles about 2-Methyl-6-trifluoroMethyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-(2-nitro-4-trifluoromethylphenyl)propan-2-one (57330-58-2) → 2-methyl-6-(trifluoromethyl)-1H-indole (57330-48-0)

Guidance literature:

With carbon monoxide; cyclopentadienyl iron(II) dicarbonyl dimer; In toluene; at 120 ℃; for 5h;

Reference yield: 81.0%

aqueous ammonium acetate + 1-(2-nitro-4-trifluoromethylphenyl)propan-2-one (57330-58-2) → 2-methyl-6-(trifluoromethyl)-1H-indole (57330-48-0)

Guidance literature:

titanium chloride; In ethanol;

Reference yield: 69.0%

C10H8F3N3 (1054567-26-8) → 2-methyl-6-(trifluoromethyl)-1H-indole (57330-48-0)

Guidance literature:

With rhodium(II) octanoate; In 1,2-dichloro-ethane; at 60 ℃; for 16h; Molecular sieve;

DOI:10.1002/anie.200800689

upstream raw materials:

1-(2-nitro-4-trifluoromethylphenyl)propan-2-one

C₁₀H₈F₃N₃

C₁₀H₈F₃N₃

1-bromo-4-trifluoromethyl-2-nitrobenzene

Refernces

• 1、 Zhang, Song-Lin,Yu, Ze-Long. "Divergent synthesis of indoles, oxindoles, isocoumarins and isoquinolinones by general Pd-catalyzed retro-aldol/α-arylation". supporting information. p. 10511 - 10515. Retrieved 2016/11/18.
• 2、 -. "Process for producing indole compound". Page/Page column 7-8. . Retrieved 2008/06/13.