5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione

Base Information

Chemical Name:5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione
CAS No.:1239610-72-0
Molecular Formula:C18H20ClNO3S
Molecular Weight:365.881
Hs Code.:
Mol file:1239610-72-0.mol

Synonyms:5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione

Suppliers and Price of 5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]methylene]-2,4-thiazolidinedione
500mg
$ 1320.00

AK Scientific
5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]methylene]-2,4-thiazolidinedione
100mg
$ 719.00

Total 2 raw suppliers

Chemical Property of 5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione

Chemical Property:

PSA：84.19000
LogP:5.28900

Purity/Quality:

99% ^*data from raw suppliers

5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]methylene]-2,4-thiazolidinedione ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione is a thiazolidinedione analogue prepared for use as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor and wound healing promoter.

Technology Process of 5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione

There total 3 articles about 5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1239610-72-0
5-[3-chloro-4-(2-cyclohexylethoxy)benzylidene]-1,3-thiazolidine-2,4-dione

Guidance literature:

Reference yield: 88.0%

: 2295-31-0
thiazoline-2,4-dione

: 1234322-99-6
3-chloro-4-(2-cyclohexylethoxy)benzaldehyde

: 1239610-72-0
5-[3-chloro-4-(2-cyclohexylethoxy)benzylidene]-1,3-thiazolidine-2,4-dione

Guidance literature:: With piperidine; acetic acid; In toluene; for 12h; Reflux;
DOI:10.1021/jm200390u

Reference yield:

: 4442-79-9
cyclohexylethan-1-ol

: 2420-16-8
4-hydroxy-3-chlorobenzaldehyde

: 1239610-72-0
5-[3-chloro-4-(2-cyclohexylethoxy)benzylidene]-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 18 h / 25 °C

2: piperidine; acetic acid / toluene / 12 h / Reflux

With piperidine; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; 1: Mitsunobu coupling reaction / 2: Knoevenagel condensation;
DOI:10.1021/jm200390u